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Postantifungal Effect of Micafungin against the Species Complexes of Candida albicans and Candida parapsilosis.

Os dejo el resumen de nuestro trabajo científico publicado en PLos One sobre la actividad  postantifúngica del fármaco micafungina contra Candida albicans, Candida dubliniensis Candida parapsilosis (y dos especies relacionadas estrechamente con esta, Candida metapsilosis y Candida orthopsilosis). Felicito a mis colegas Sandra Gil-Alonso, Nerea Jauregizar y Elena Eraso de la Facultad de Medicina de la Universidad del País Vasco (UPV/EHU) en Bilbao, por su excelente trabajo.

El trabajo completo se puede leer en la página de la revista PLoS One de forma libre y gratuita.

Este es su Resumen:

Micafungin is an effective antifungal agent useful for the therapy of invasive candidiasis.Candida albicans is the most common cause of invasive candidiasis; however, infections due to non-C. albicans species, such as Candida parapsilosis, are rising. Killing and postantifungal effects (PAFE) are important factors in both dose interval choice and infection outcome. The aim of this study was to determinate the micafungin PAFE against 7 C. albicans strains, 5 Candida dubliniensis, 2 Candida africana, 3 C. parapsilosis, 2 Candida metapsilosis and 2 Candida orthopsilosis. For PAFE studies, cells were exposed to micafungin for 1 h at concentrations ranging from 0.12 to 8 μg/ml. Time-kill experiments (TK) were conducted at the same concentrations. Samples were removed at each time point (0-48 h) and viable counts determined. Micafungin (2 μg/ml) was fungicidal (≥ 3 log10 reduction) in TK against 5 out of 14 (36%) strains of C. albicans complex. In PAFE experiments, fungicidal endpoint was achieved against 2 out of 14 strains (14%). In TK against C. parapsilosis, 8 μg/ml of micafungin turned out to be fungicidal against 4 out 7 (57%) strains. Conversely, fungicidal endpoint was not achieved in PAFE studies. PAFE results for C. albicans complex (41.83 ± 2.18 h) differed fromC. parapsilosis complex (8.07 ± 4.2 h) at the highest tested concentration of micafungin. In conclusion, micafungin showed significant differences in PAFE against C. albicans and C.parapsilosis complexes, being PAFE for the C. albicans complex longer than for the C.parapsilosis complex.

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