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Effect of biomaterials hydrophobicity and roughness on biofilm development

Este es el resumen de nuestro trabajo científico «Effect of biomaterials hydrophobicity and roughness on biofilm development» que ha sido publicado en la revista Journal of Materials Science: Materials in Medicine. Este trabajo forma parte de la Tesis de Doctorado de Iker De la Pinta, que dirigimos Teresa Guraya y yo. Esta Tesis se defenderá el próximo jueves 14 de noviembre en la Facultad de Medicina y Enfermería.

Felicito a mis colegas Iker De-la-Pinta, Mónica Cobos, Julen Ibarretxe, Elisabeth Montoya, Elena Eraso y Teresa Guraya, por su excelente trabajo. Agradezco a Francisco José Álvarez y Hector Lafuente (BioCruces Health Research Institute) y a Ane Miren Zaldua (Leartiker Polymer R&D) por su inestimable ayuda.

El trabajo completo está en Journal of Materials Science: Materials in Medicine  (no es de acceso libre)

Este es su Resumen:

Most hospitalized patients are carriers of biomedical devices. Infections associated with these devices cause great morbidity and mortality, especially in patients in intensive care units. Numerous strategies have been designed to prevent biofilm development on biodevices. However, biofilm formation is a complex process not fully clarified. In the current study, roughness and hydrophobicity of different biomaterials was analyzed to assess their influences on the biofilm formation of four leading etiological causes of healthcare-associated infections, Escherichia coliPseudomonas aeruginosaStaphylococcus epidermidis and Candida albicans, using a CDC biofilm reactor. Hydrophobic materials allowed the formation of more abundant and profuse biofilms. Roughness had effect on biofilm formation, but its influence was not significant when material hydrophobicity was considered.

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