University of the Basque Country University of the Basque Country

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Faculty of Science and Technology

Faculty of Science and Technology
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w_MolNucleoProts

Molecular mechanisms governing normal and pathogenic functionality of nuclear proteins (MolNucleoProts)

 

Department (s)
Biochemistry and Molecular Biology
Knowledge area
Biochemistry; Molecular Biology; Biophysics; Proteins
PI: Sonia Bañuelos Co-PI: 

Members

Sonia Bañuelos and David López

Keywords

Nucleophosmin; NPM1; APE1; DNA repair; AML leukaemia

Description

Our research is focused on the structure - function relationship of nuclear proteins implicated in human pathologies. We currently study two proteins, nucleophosmin (NPM1) and APE1, involved in the cell stress response and the DNA damage repair. NPM1 is mutated, unfolded and aberrantly dislocated to cytoplasm in a subtype of acute myeloid leukemia (AML). Our present aim is contributing to unravel the role of nucleophosmin in DNA repair mechanisms and how it could underlay pathologic alterations and moreover, be targeted for therapeutic purpose. Recently, we have also engaged in a project aimed to the application of virus-like nanoparticles for display of nucleophosmin neoantigens, which might be pharmacologically useful for immunotherapy of AML.

Research lines

  1. Regulatory mechanisms in the DNA repair protein APE1.
  2. Design and production of VLPs decorated with neoantigenic peptides of AML leukaemia. (Collaboration with Dr. Diego Guérin)

Equipment

 

Website link

 

Contact

sonia.banuelos@ehu.es