Cancer Transcription & Cell Comunication Lab
| Saila(k) Bioquímica y Biología Molecular |
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| Zientziaren esparrua(k) Biomedicina |
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| Ikertzaile Nagusia (IN): Verónica Torrano Moya | IN-laguna: | |
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Partaideak Verónica Torrano, Ivana Hermanova, Alice Macchia, Ariane Schaub, Ainara Pintor, Patricia Gangoiti, Lorea Valcarcel (2022), Benoit Lectez (2022), David López |
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Hitz gakoak Cáncer, transcripción, metabolismo, comunicación celular |
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Deskribapena During tumorigenesis, cancer cells overcome biological challenges such as moving across the tissue of origin, escaping from the primary tumor, acquiring therapy-resistance and colonizing distal organs. The success of the tumor evolution process rely on the ability of cancer cells to face and adapt to all these biological scenarios, environmental perturbations and ultimately generate a metastatic lesion. In the lab we have previously demonstrated that the transcriptome analysis of publicly available cancer databases is a valid approach for the identification of relevant genes for the progression and adaptation of prostate cancer (PCa) cells (Torrano et al. Nature Cell Biology 2016; Valcarcel et al. Cell Death & Disease 2018; Cortazar et al. Cancer Research 2018; Valcarcel et al. Cancer Research 2019). Today we know that the adaptation skill that cancer cells acquired is nourished not only by the deregulation of cell-autonomous mechanism but also by the communication of cancer cells and the stroma. Aligning these ideas, we are now working on the transcriptional deregulation of secretome genes as drivers for the acquisition of aggressive properties by prostate cancer (PCa) cells and their functional impact on the biology and progression of the disease. |
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Ikerketa-Lerroak Based on a multidisciplinary approach, from bioinformatics to cell biology, we have conceived our projects with the aim to build the foundations for solid hypothesis-driven approaches to identify genes functionally involved in PCa cancer biology, specifically those related to cell communication. We integrate bioinformatics screening of publicly available databases and functional assays with the final goal to exploit the potential of secretome-related genes for PCa therapy. The core line of research in our lab starts with studying WHAT secretome genes do in PCa, HOW we can pharmacologically counteract the consequences derived from their modulation and WHO could benefit of this therapeutic approach. Thus, we envision that our lines of research will have the potential to inform us not only on the risk of recurrence and metastasis but also to give light on new therapeutic strategies against the most aggressive types of PCa. |
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