{"id":766,"date":"2008-12-12T01:23:00","date_gmt":"2008-12-12T00:23:00","guid":{"rendered":"http:\/\/www.ehu.es\/chemistry\/theory\/wordpress\/?p=766"},"modified":"2026-03-11T12:00:43","modified_gmt":"2026-03-11T11:00:43","slug":"elixabete-rezabal","status":"publish","type":"reserchers","link":"https:\/\/www.ehu.eus\/chemistry\/theory\/reserchers\/elixabete-rezabal\/","title":{"rendered":"Prof. Elixabete Rezabal"},"content":{"rendered":"
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2025<\/h3>
33.<\/div>

Cartagena, Manuel Eduardo Martinez; Suarez, Lucia; Ontoria, Aitor; Benitez, Francisca J.; Rezabal, Elixabete; Orellano, Mar\u00eda Soledad; Calder\u00f3n, Marcelo; Huck\u2010Iriart, Cristi\u00e1n; Picco, Agustin S.; Picchio, Matias L.; Beloqui, Ana<\/p>

Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis<\/a> Journal Article<\/span> <\/p>

In: <\/span>Advanced Materials, <\/span>2025<\/span>, ISSN: 1521-4095<\/span>.<\/p>

Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span><\/p>

@article{MartinezCartagena2025,
\r\ntitle = {Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis},
\r\nauthor = {Manuel Eduardo Martinez Cartagena and Lucia Suarez and Aitor Ontoria and Francisca J. Benitez and Elixabete Rezabal and Mar\u00eda Soledad Orellano and Marcelo Calder\u00f3n and Cristi\u00e1n Huck\u2010Iriart and Agustin S. Picco and Matias L. Picchio and Ana Beloqui},
\r\ndoi = {10.1002\/adma.202517014},
\r\nissn = {1521-4095},
\r\nyear  = {2025},
\r\ndate = {2025-12-24},
\r\nurldate = {2025-12-24},
\r\njournal = {Advanced Materials},
\r\npublisher = {Wiley},
\r\nabstract = {<jats:title>ABSTRACT<\/jats:title>
\r\n                  <jats:p>The development of soft hybrid materials that combine structural integrity, biocompatibility, and catalytic function is a central challenge in advanced biocatalysis. Here, we introduce eutectozymes, enzyme\u2010loaded eutectogels built from natural hydrophobic deep eutectic solvents (HES) and stabilized through a dual supramolecular polymeric network. This unique architecture not only preserves the conformational integrity of enzymes but also creates confined microcavities acting as protective microreactors, thereby enhancing their stability and substrate affinity. Eutectozymes exhibit remarkable resilience under harsh operational conditions, including high temperatures, extreme pH, and organic solvents, while maintaining high catalytic efficiency and reusability. Their versatility is further demonstrated in environmental remediation, achieving over 90% degradation of recalcitrant dyes, and in antimicrobial applications against resistant bacterial strains. By synergistically merging the stabilizing properties of HES with robust gel matrices, eutectozymes establish a transformative platform for heterogeneous biocatalysis, opening new avenues in biotechnology, bioelectronics, and environmental technologies.<\/jats:p>},
\r\nkeywords = {},
\r\npubstate = {published},
\r\ntppubtype = {article}
\r\n}
\r\n<\/pre><\/div>
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<jats:title>ABSTRACT<\/jats:title>
\r\n                  <jats:p>The development of soft hybrid materials that combine structural integrity, biocompatibility, and catalytic function is a central challenge in advanced biocatalysis. Here, we introduce eutectozymes, enzyme\u2010loaded eutectogels built from natural hydrophobic deep eutectic solvents (HES) and stabilized through a dual supramolecular polymeric network. This unique architecture not only preserves the conformational integrity of enzymes but also creates confined microcavities acting as protective microreactors, thereby enhancing their stability and substrate affinity. Eutectozymes exhibit remarkable resilience under harsh operational conditions, including high temperatures, extreme pH, and organic solvents, while maintaining high catalytic efficiency and reusability. Their versatility is further demonstrated in environmental remediation, achieving over 90% degradation of recalcitrant dyes, and in antimicrobial applications against resistant bacterial strains. By synergistically merging the stabilizing properties of HES with robust gel matrices, eutectozymes establish a transformative platform for heterogeneous biocatalysis, opening new avenues in biotechnology, bioelectronics, and environmental technologies.<\/jats:p><\/div>
Close<\/a><\/p><\/div>