University of the Basque Country University of the Basque Country

Cabecera Cofund

Advanced Manufacturing Research Fellowship Programme Adagio

Advanced ManufacturIng Research Fellowship Programme in the Basque - New Aquitaine Region (ADAGIO)

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Host Research Group

ES6_PolyZymes_Ana Beloqui Elizazu

Ana Beloqui

943 018838

ana.beloquie@ehu.eus

https://anabeloqui1982.wixsite.com/polyzymes

Group description

Our group is focused on the development of chemical tools to leverage the utilization of enzymes as catalysts in sustainable processes. The utilization of enzymes permits the implementation of greener and less hazardous synthesis procedures. However, the stability of the biocatalyst under reaction conditions is usually jeopardized. Therefore, in our group, we develop several chemical tools, mainly based in the design of tailored polymers, to protect and avoid the inactivation of the biocatalysts under harsh conditions. One of the processes in which we want to test our stabilized catalytic hybrids is in the synthesis or degradation of polymers, in which the high temperatures, the presence of organic solvents or/and reactive radicals can have a detrimental effect over the protein.

Keywords

  • Enzymes
  • Green Synthesis
  • Catalytic materials

Team Description

  • Ana Beloqui (Principal Investigator (Ramón y Cajal))

    ORCID: 0000-0002-7693-4163

  • Daniel Sánchez (Post-Doctoral Researcher)

    ORCID: 0000-0001-6034-8525

  • Pablo Muñumer (PHD Students)

  • Andoni Rodriguez (PHD Students)

  • Rocío López (PHD Students)

Projects

  • Application of solid-phase methods for the oriented patching of proteins (HidroParch)

    Pl: Ana Beloqui

    Funding Agency*: BBVA Foundation

    Ongoing: yes

    Project reference: FP21/10

  • Polymeric platforms for efficient (photo)chemoenzymatic reactions

    Pl: Ana Beloqui

    Funding Agency*: Spanish Research Agency

    Ongoing: yes

    Project reference: MINECOR19/P07

  • Nanovehículos inteligentes para el tratamiento del glioblastoma

    Pl: Ana Beloqui

    Funding Agency*: Diputación Gipuzkoa

    Ongoing: yes

  • Design and production of new nanostructures hybrid materials for their application in heterogeneous catalysis

    Pl: Ana Beloqui

    Funding Agency*: Spanish Research Agency

    Ongoing: no

  • Development of Stable hybrid nanomaterials with (bio)catalytic properties for technological and industrial applications

    Pl: Ana Beloqui

    Funding Agency*: Basque Government

    Ongoing: no

* INT - International EU - European NAT - National RE - Regional

Publications

  • A. Beloqui, S. R. Mane, M. Langer, M. Glassner, D. M. Bauer, L. Fruk, C. Barner-Kowollik, and G. Delaittre, = Hetero-Diels–Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform, Angewandte Chemie International Edition, 2020
    10.1002/anie.202005747

  • A. Rodriguez-Abetxuko, P. Muñumer, M. Okuda, J. Calvo, M. Knez, and A. Beloqui, = Nanoconfined (bio)catalysts as efficient glucose responsive nanoreactors, Advanced Functional Materials, 2020
    10.1002/adfm.202002990

  • A. Rodriguez-Abetxuko; D. Sánchez-deAlcázar; A. L. Cortajarena; A. Beloqui, = A versatile approach for the assembly of highly tunable biocatalytic thin films, Advanced Materials Interfaces, 2019
    10.1002/admi.201900598

  • A. Rodriguez-Abetxuko; M. C. Morant-Miñana; F. Lopez-Gallego; L. Yate; A. Seifert; M. Knez; A. Beloqui, = Imidazole grafted nanogels for the fabrication of organic-inorganic protein hybrids, Advanced Functional Materials, 2018
    10.1002/adfm.201803115

  • A. Beloqui*; A.Y. Kobitski; G.U. Nienhaus; G. Delaittre*, = A Simple Route to Highly Active Single-Enzyme Nanogels, Chemical Science, 2018
    10.1039/C7SC04438K

Research Lines

SUSTAINABLE MANUFACTURING

Use of Enzymes to enable greener approaches in recycling and manufacturing processes

In our group, we aim to apply the enzymes that we stabilize in the lab into the process of synthesis/recycling of polymers. Most of the commercial enzymes that are currently used for this propose are not stable enough to reach high conversion rates and, thus, make the process economically unfavorable. Therefore, there is a need to manipulate the biocatalyst to make them work under these conditions with high catalytic rates. With the development of an adapted biocatalyst, new processes in which less harmful reaction conditions are designed, we would step forward the development of greener and more sustainable manufacturing processes.

Cross-border Collaboration (if any)

POLYMAT actively collaborates with several research groups at University of Bordeaux. Indeed, in the last years our researchers have participated in 3 European Projects either in the seventh framework programme (FP7) and in H2020, together with partners from University of Bordeaux:

FP7-Renaissance-ITN-2012-289347. Coordinated by UPV/EHU-POLYMAT

H2020-SUSPOL-EJD-2017-642671.Coordinated by UPV/EHU-POLYMAT

H2020-PEPTICAPS-NMP-2015-686141

In addition, several PhD thesis in cotutelle with the laboratory of LCPO (Prof. Daniel Taton and Prof. Henri Cramail) are currently running and have been accomplished within the last years.

On the other hand, a Joint Double Master Program in Polymer Science between the University of the Basque Country and the University of Bordeaux with the advisory board formed by POLYMAT researchers Prof. JR. Leiza and M. Paulis