Aintzane Apraiz

Introduction

Phone: 94 601 2950
Emailaintzane.apraiz@ehu.es
Office Location: School of Medicine and Dentistry, First Floor, office 104
Research Group: MOLECULAR BIOLOGY OF CANCER

Teaching Profile

Since the end of 2012, I am a lecturer at the Department of Cell Biology and Histology of the University of the Basque Country (UPV/EHU). I currently teach the following compulsory subjects in the Degrees in Physiotherapy and in Medicine: Biochemical, Cellular and Histological bases of Physiotherapyand Research Project (in Basque, language), Basic Medical Histology and Special Medical Histology (in Spanish language).

Research Profile

I earned my PhD in 2010 at the University of the Basque Country (UPV/EHU) (Department of Cell Biology and Histology)with a project on the cellular mechanisms triggered by synthetic retinoids (anti-tumor compounds) and mediated by sphingolipids. I carried out a predoctoral research stage at the Department of Biochemistry and Molecular Biology of the Medical University Southern Carolina (USA), which specializes in the study of the biological activities of sphingolipids. After I received my PhD, I joined the research group led by Dr. Ana Maria Zubiagain 2011, and began my studieson the transcriptional regulation mediated by members of the E2F family.

Research Projects

Título del proyecto: Investigación estratégica y desarrollo tecnológico aplicado a metabolismo-enfermedad y cáncer-envejecimiento
Entidad financiadora: GOBIERNO VASCO, Departamento Industria, Comercio y Turismo. Ref.: IE12-331
Investigador responsable: ZUBIAGA, ANA MARIA
Número de investigadores participantes: 12
Fecha inicio: 01/01/2012  Fecha fin: 31/12/2014

Título del proyecto: Grupo de Investigación del Sistema Universitario Vasco. Mecanismos moleculares implicados en la alteración de la homeostasis celular: perspectivas para la terapia del cáncer
Entidad financiadora: GOBIERNO VASCO, Departamento Educación. Ref.: IT634-13
Entidades participantes: Universidad del País Vasco (UPV/EHU)
Investigador responsable: ZUBIAGA, ANA MARIA
Número de investigadores participantes: 16
Fecha inicio: 01/01/2013  Fecha fin: 31/12/2018

Selected publications (last 5 years)

1. An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.
Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM.
Nucleic Acids Res. 2018 Mar 24. doi: 10.1093/nar/gky218. [Epub ahead of print]
 

2. Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols.
Apraiz A, Mitxelena J, Zubiaga A.
J Vis Exp. 2017 Jun 6;(124). doi: 10.3791/55745.
 

3. E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation.
Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM.
Nucleic Acids Res. 2016 Mar 9. pii: gkw146. [Epub ahead of print]
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4. E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.
Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez JA, Fullaondo A, Zubiaga AM.
Nucleic Acids Res. 2013 Dec;41(22):10185-98. doi: 10.1093/nar/gkt821. Epub 2013 Sep 12.
 

5. 1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.
Manterola L, Hernando-Rodríguez M, Ruiz A, Apraiz A, Arrizabalaga O, Vellón L, Alberdi E, Cavaliere F, Lacerda HM, Jimenez S, Parada LA, Matute C, Zugaza JL.
Transl Psychiatry. 2013 Jan 22;3:e219. doi: 10.1038/tp.2012.147.
 

6. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.
Apraiz A, Idkowiak-Baldys J, Nieto-Rementería N, Boyano MD, Hannun YA, Asumendi A.
Biochem Cell Biol. 2012 Apr;90(2):209-23. doi: 10.1139/o2012-001. Epub 2012 Mar 19.