Publications

Selected publications of the last 5 years.

  •  An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM. Nucleic Acids Res. 2018; doi: 10.1093/nar/gky218. 
  • Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay. Iglesias-Ara A, Osinalde N, Zubiaga AM. Methods Mol Biol. 2018;1726:153-166. doi: 10.1007/978-1-4939-7565-5_14.
  • SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease. Tomasi ML, Ramani K, Ryoo M, Cossu C, Floris A, Murray BJ, Iglesias-Ara A, Spissu Y, Mavila N. FASEB J. 2018 :fj201701124R. doi: 10.1096/fj.201701124R. 
  • S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. Oncotarget. 2017; 8(45):78851-78869. doi: 10.18632/oncotarget.20234. 
  • The stress of coping with E2F loss. Iglesias-Ara A, Zubiaga AM. Mol Cell Oncol. 2015. 3(1):e1038423. doi: 10.1080/23723556.2015.1038423. 
  • Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes. Osinalde N, Mitxelena J, Sánchez-Quiles V, Akimov V, Aloria K, Arizmendi JM, Zubiaga AM, Blagoev B, Kratchmarova I. Mol Cell Proteomics. 2016; 15(6):2076-92. doi: 10.1074/mcp.M115.057158. 
  • E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM. Nucleic Acids Res. 2016; pii: gkw146. 
  • Proteome-wide search for functional motifs altered in tumors: Prediction of nuclear export signals inactivated by cancer-related mutations. Prieto G, Fullaondo A, Rodríguez JA. Sci Rep. 2016 May 12;6:25869. doi: 10.1038/srep25869.
  • LDLR and PCSK9 Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA Carriers. Ochoa E, Iriondo M, Manzano C, Fullaondo A, Villar I, Ruiz-Irastorza G, Zubiaga AM, Estonba A. PLoS One. 2016;11(1):e0146990. doi: 10.1371/journal.pone.0146990. 
  • Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene. Valcárcel-Ocete L, Alkorta-Aranburu G, Iriondo M, Fullaondo A, García-Barcina M, Fernández-García JM, Lezcano-García E, Losada-Domingo JM, Ruiz-Ojeda J, Álvarez de Arcaya A, Pérez-Ramos JM, Roos RA, Nielsen JE, Saft C; REGISTRY investigators of the European Huntington's Disease Network, Zubiaga AM, Aguirre A. PLoS One. 2015;10(7):e0131573. doi: 10.1371/journal.pone.0131573. 
  •  E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Iglesias-Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga AM. Cell Death Differ. 2015;22(10):1577-89. doi: 10.1038/cdd.2015.4. 
  • Prediction of nuclear export signals using weighted regular expressions (Wregex). Prieto G, Fullaondo A, Rodriguez JA. Bioinformatics. 2014;30(9):1220-7. doi: 10.1093/bioinformatics/btu016.
  • Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice. Tomasi ML, Ryoo M, Yang H, Iglesias Ara A, Ko KS, Lu SC. Free Radic Biol Med. 2014;68:148-58. doi: 10.1016/j.freeradbiomed.2013.11.018. .
  • E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes. Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez JA, Fullaondo A, Zubiaga AM. Nucleic Acids Res. 2013;41(22):10185-98. doi: 10.1093/nar/gkt821. 
  • Thrombotic antiphospholipid syndrome shows strong haplotypic association with SH2B3-ATXN2 locus. Ochoa E, Iriondo M, Bielsa A, Ruiz-Irastorza G, Estonba A, Zubiaga AM. PLoS One. 2013;8(7):e67897. doi: 10.1371/journal.pone.0067897. 
  • The nuclear protein ALY binds to and modulates the activity of transcription factor E2F2. Osinalde N, Olea M, Mitxelena J, Aloria K, Rodriguez JA, Fullaondo A, Arizmendi JM, Zubiaga AM. Mol Cell Proteomics. 2013;12(5):1087-98. doi: 10.1074/mcp.M112.024158. 

Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/ dATP stimulated lysates of NSCLC cells

Authors:
Checinska A, Giaccone G, Rodriguez JA, Kruyt FAE, Jimenez CR.
Year:
Journal:
J Proteom
Volume:
72
Initial page - Ending page:
575 - 585