Acronym: ENGINANO-HF

Specific programme: Marie Skłodowska-Curie actions (MSCA)

UPV/EHU Partner Status: Single beneficiary

UPV/EHU PI: MARCELO CALDERON

Project start: 01/06/2022

Project end: 31/05/2024

Brief description: Alopecia areata (AA) is a common autoimmune disorder resulting from damage of the hair follicle by cytotoxic T cells and characterized by nonscarring hair loss. EngiNano-HF will focus on advancing the Experienced Researcher’s career through the development of the technology and manufacture stages of a new supramolecular polymer nanoformulation for the successful management of Janus kinase-inhibitors to prevent AA and associated complications. Under the supervision of Prof. M. Calderón, a globally recognized researcher, EngiNano-HF will proceed in a stepwise fashion using cutting-edge methodologies to prepare and physicochemically characterize the polymer nanocarriers. The effect of the nanocarrier size, surface chemistry, surface charge, and mechanical properties on the hair follicle penetration and follicular delivery will be evaluated in porcine ear skin ex-vivo models. The most promising formulations will then be validated on a pre-industrial scale.