Presentation

Biochemistry Grade. PhD in Physiology by UPV/EHU.

Associate Professor at UPV/EHU.

Teaching profile

Medicine School:

"General Physiology" and "Researching project" in Medicine.

"Physiology and Nutritión" and "Biochemistry" in Dentistry.

Science School:

"Human Physiology " in Biochemistry and Molecular Biology.

Researching profile

I obtain my PhD degree in 2007 in the University of the Basque Country (UPV/EHU) with a work about polymorphisms associated to the result of a in vitro fertilization therapy. I started my postdoctoral research in The Center for Applied Medical Research (CIMA), University of Navarra (2007-2009), in Gene Therapy and Viral Hepatitis. Later I moved back to UPV/EHU (2009-2011), to Dr. Aspichueta's group, who is working in metabolic alterations associated to Non Alcoholic Fatty Liver Disease (NAFLD). Since I returned to UPV/EHU in 2009 I am working with Dr. Aspichueta and her group in different projects including metabolism, ageing, cancer... We use experimental models including cell cultures and animal models.

Publications

Francisco Gonzalez-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O’Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela-Rey, Marta Palomo-Irigoyen, Beatriz Gomez-Santos, Diego Saenz de Urturi, Maitane Nuñez-García, Juan L. García-Rodríguez, Larraitz Fernandez-Ares, Xabier Buque, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C. Delgado, Naroa Goikoetxea-Usandizaga, Richard Lee, Sanjay Bhanot, Igotz Delgado, Maria J. Perugorria, Gaizka Errazti, Lorena Mosteiro, Sonia Gaztambide, Idoia Martinez de la Piscina, Paula Iruzubieta, Javier Crespo, Jesus M. Banales, Maria L. Martínez-Chantar, Luis Castaño, Ana M. Zubiaga, and Patricia Aspichueta. E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment. (Cancer Research. 2021 Vol. 81(11) 2874-2887.

Beatriz Gómez-Santos, Diego Saenz de Urturi, Maitane Nuñez-García, Francisco Gonzalez-Romero, Xabier Buque, Igor Aurrekoetxea, Virginia Gutiérrez de Juan, Maria J Gonzalez-Rellan, Carmelo García-Monzón, Águeda González-Rodríguez, Lorena Mosteiro, Gaizka Errazti, Patricia Mifsut, Sonia Gaztambide, Luis Castaño, Cesar Martin, Rubén Nogueiras, María L Martinez-Chantar, Wing-Kin Syn, Patricia Aspichueta. Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. (Aging Cell. 2020 Vol. 19(8)

Marta Iruarrizaga-Lejarreta, Marta Varela-Rey, David Fernandez-Ramos, Ibon Martınez-Arranz, Teresa C Delgado, Jorge Simon, Virginia Gutierrez-de Juan, Laura delaCruz-Villar, Mikel Azkargorta, Jose L. Lavin, Rebeca Mayo, Sebastiaan M. Van Liempd, Igor Aurrekoetxea, Xabier Buque, Donatella Delle Cave, Arantza Peña, Juan Rodrıguez-Cuesta, Ana M. Aransay, Felix Elortza, Juan M. Falcon-Perez, Patricia Aspichueta, Liat Hayardeny, Mazen Noureddin, Arun J. Sanyal, Cristina Alonso, Juan Anguita, Marıa Luz Martınez-Chantar, Shelly C. Lu, and Jose M. Mato. Role of Aramchol in Steatohepatitis and Fibrosis in Mice. (Hepatology Communications. 2017 Vol. 1(9) 911-927.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. (Cell Metab. 2017 Vol. 26(1) 212-229.

Imanol Zubiete-Franco, Pablo Fernández-Tussy, Lucía Barbier-Torres, Jorge Simon, David Fernández-Ramos, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de Juan, Sergio López de Davalillo, Antonio Martín Duce, Paula Iruzubieta, Daniel Taibo, Javier Crespo, Juan Caballeria, Erica Villa, Igor Aurrekoetxea, Patricia Aspichueta, Marta Varela-Rey, Shelly C. Lu, José M. Mato, Naiara Beraza, Teresa C. Delgado, María L. Martínez-Chantar. Deregulated neddylation in liver fibrosis. (Hepatology. 2016 Vol. 65(2) 694–709.

Jose A. Gomez-Sanchez, Lucy Carty, Marta Iruarrizaga-Lejarreta, Marta Palomo-Irigoyen, Marta Varela-Rey, Megan Griffith, Janina Hantke, Nuria Macias-Camara, Mikel Azkargorta, Igor Aurrekoetxea, Virginia Gutiérrez De Juan, Harold B.J. Jefferies, Patricia Aspichueta, Félix Elortza, Ana M. Aransay, María L. Martínez-Chantar, Frank Baas, José M. Mato, Rhona Mirsky, Ashwin Woodhoo, Kristján R. Jessen. Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves. (J. Cell. Biol. 2015 Vol. 210(1) 153-168).

Igor Aurrekoetxea. "Pildorón": ¿El fármaco del futuro?. (IKD-Baliabideak UPV/EHU. Revista on-line) web: http://cvb.ehu.es/ikd-baliabideak/aurrekoetxea-09-2015.htm

Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, de Juan VG, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Luz Martínez-Chantar M, Mato JM, Aspichueta P. S-adenosylmethionine increases circulating very-low density lipoprotein clearance in nonalcoholic fatty liver disease. (J Hepatol. 2014 Oct 62; 673-681).

Martinez-Uña M, Varela M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martinez-Arranz I, García-Rodriguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martinez-Chantar ML, Aspichueta P, Mato JM. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis. (Hepatology. 2013 Mar 58 (4); 1296-1305).

Ainara Cano, Xabier Buqué, Maite Martinez-Uña, Igor Aurrekoetxea, Ariane Menor, Juan L García-Rodriguez, Shelly C Lu, M. Luz Martinez-Chantar, Jose M. Mato, Begoña Ochoa, Patricia Aspichueta. Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice. (Hepatology. 2011 Dec 54 (6); 1975-86).

Donatello S, Hudson L, Cottell DC, Blanco A, Aurrekoetxea I, Shelly MJ, Dervan PA, Kell MR, Stokes M, Hill AD, Hopkins AM. An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models. (J Exp Clin Cancer Res. 2011 Apr 26;30(1):45.).

José Ignacio Ruiz-Sanz, Igor Aurrekoetxea, Roberto Matorras, María Begoña Ruiz-Larrea. Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles. (Fertility and Sterility, 2011; vol.95(5); 1601-5).

Ainhoa Ruiz del Agua, Igor Aurrekoetxea, Miguel Ángel Elorriaga, Fernando Rodriguez, Françoise Guéraud, María Begoña Ruiz-Larrea, José Ignacio Ruiz-Sanz. Involvement of G-463A MPO gene polymorphism in the response of post-menopausal women to hormone therapy. (Menopause, 2011; vol.18 (5); 575-81).

Igor Aurrekoetxea, José Ignacio Ruiz-Sanz, Ainhoa Ruiz del Agua, Rosaura Navarro, M. Luisa Hernández, Roberto Matorras, Begoña Prieto, María Begoña Ruiz-Larrea. Serum oxidizability and antioxidant status in patients undergoing in vitro fertilization. (Fertility and Sterility, 2010; 94(4):1279-86).

Julien Crettaz, Itziar Otano, Laura Ochoa, Alberto Benito, Astrid Paneda, Igor Aurrekoetxea, Pedro Berraondo, Juan Roberto Rodríguez-Madoz, Aurora Astudillo, Florian Kreppel, Stefan Kochanek, Juan Ruiz, Stephan Menne, Jesus Prieto, Gloria Gonzalez-Aseguinolaza. Treatment of chronic viral hepatitis in woodchucks by prolonged intrahepatic expression of Interleukin-12. (Journal of Virology, 2009; vol.83; 2663-2674).

Julien Crettaz, Cristina Olagüe, Africa Vales, Igor Aurrekoetxea, Pedro Berraondo, Itziar Otano, Stefan Kochanek, Jesus Prieto, Gloria Gonzalez-Aseguinolaza. Characterization of high-capacity adenovirus production by the quantitative real-time polymerase chain reaction: a comparative study of different titration methods. (J Gene Med., 2008; vol 10; 1092-1101).

José Ignacio Ruiz-Sanz, Igor Aurrekoetxea, Ainhoa Ruiz del Agua, María Begoña Ruiz-Larrea. Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR. (Molecular and Cellular Probes, 2007; vol 21; 202-207).

Rosa Martínez, Rosaura Navarro, César Martín, Igor Aurrekoetxea, M. Luisa Hernández, Mercedes Lacort, José Ignacio Ruiz-Sanz, and M. Begoña Ruiz-Larrea. Doxorubicin increases intracellular diacylglycerol by the mobilization of choline-enriched phospholipids in rat hepatocytes. (Annal. NY Acad. Sci., 2002; vol 973; 49-51).

Rosa Martínez, Rosaura Navarro, César Martín, Igor Aurrekoetxea, M. Luisa Hernández, Mercedes Lacort, José Ignacio Ruiz-Sanz, and M. Begoña Ruiz-Larrea. Intracellular diacylglycerol accumulation induced by doxorubicin in rat hepatocytes: potential involvement of phospholipases C and D. (Annal. NY Acad. Sci., 2002; vol 973; 52-6).

R Martínez, K Quintana, C Martín, R Navarro, ML Hernádez, I Aurrekoetxea, JI Ruiz-Sanz, M Lacort, MB Ruiz-Larrea. Pro-oxidant and antioxidant potencial of catecholestrogens againts ferrylmyoglobin-induced oxidative stress. (Biochim Biophys Acta, Jul 2002; vol 1583 (2); 167-175).