De Grupo de Inteligencia Computacional (GIC)

Darya Chyzhyk

“Little by little, one travels far”. ― J.R.R. Tolkien.


Google Scholar


ORCID identifier is 0000-0002-9333-6122

Personal data

Ph.D. in Computer Science
Thesis title: Contributions of Lattice Computing to Medical Image Processing
Thesis advisor: Manuel Graña Romay
Facultad de Informática UPV/EHU 26 de Julio de 2013, Apto cum laude por unanimidad
Slides of the Thesis

Contact data

  • E-mail:
  • Phone number: 0034 943 01 8047
  • Address:
    • Darya Chyzhyk
    • Computational Intelligence Group
    • Computer Science Faculty - Lab. 307
    • University Of The Basque Country (UPV/EHU)
    • Paseo Manuel Lardizabal 1 - CP: 20018 Donostia-San Sebastián (GUIPUZCOA) - Spain

Reseach Areas

Medical Image Analysis, Machine learning and Image Processing.


Publicaciones internas



Manuel Graña, Leire Ozaeta, Darya Chyzhyk
Dynamic Causal Modeling and Machine Learning for Effective Connectivity in Auditory Hallucination
JCR (2014) 2.083 (Q2 CSAI) (2015) 2.392 (Q1 CSAI) (2016) 3.317


Manuel Graña, Darya Chyzhyk
Image Understanding Applications of Lattice Auto-Associative Memories
IEEE Transactions on Neural Networks and Learning Systems, (aceptdo 24 julio 2015) Volume: 27, Issue: 9, Sept. 2016 pp.1920 - 1932 [online]
DOI 10.1109/TNNLS.2015.2461451
JCR (2014) 4.291 (Q1 CSAI) (2015) 4.854


Ariadna Besga, Itxaso Gonzalez, Enrique Echeburua, Alexandre Savio, Borja Ayerdi, Darya Chyzhyk, Jose L. M. Madrigal, Juan C. Leza, Manuel Graña, Ana Maria Gonzalez-Pinto
Discrimination between Alzheimer’s Disease and Late Onset Bipolar Disorder using multivariate analysis
Frontiers in Aging Neuroscience, 2015 (7): 00231. JCR (2014) 4. ISSN=1663-4365
Manuel Graña, Darya Chyzhyk
Image Understanding Applications of Lattice Autoassociative Memories
IEEE transactions on neural networks and learning systems, 2015 (8):. JCR (2014) 4.291 ISSN: 2162-237X
Ariadna Besga-Basterra, Darya Chyzhyk, Itxaso González-Ortega, Alexandre Savio, Borja Ayerdi, Jon Echeveste, Manuel Graña, Ana González-Pinto
Eigenanatomy on fractional anisotropy imaging provides white matter anatomical features discriminating between Alzheimer's Disease and Late Onset Bipolar Disorder, (PubMed) pdf
Current Alzheimer Research, 2015. JCR (2014) 3.889 (Q1 Clin Neurol, Q2 Neurosciences), ISSN: 1875-5828 (Online), ISSN: 1567-2050 (Print)
Darya Chyzhyk, Alexandre Savio, Manuel Graña
Computer Aided Diagnosis of Schizophrenia on resting state fMRI data by Ensembles of ELM
Neural Networks (2015)68:23-33. DOI information: 10.1016/j.neunet.2015.04.002 JCR (2014) 2.708 ,(2013) 2.076 (Q1 CSAI, Q3 Neurosciences), ISSN: 0893-6080
Chyzhyk D, Graña M, Öngür D, Shinn AK.
Discrimination of Schizophrenia Auditory Hallucinators by Machine Learning of Resting-State Functional MRI.
International journal of neural systems, 25(3):1550007, 2015. pdf JCR 2014 6.056, (2015) 6.507 (Q1 CSAI), Print ISSN: 0129-0657, Online ISSN: 1793-6462
Leire Ozaeta, Darya Chyzhyk, Manuel Graña
Some Results on Dynamic Causal Modeling of Auditory Hallucinations, Artificial Computation in Biology and Medicine, Lecture Notes in Computer Science Volume 9107, 2015, pp 185-194. Ferrández Vicente, J.M., Álvarez-Sánchez, J.R., de la Paz López, F., Toledo-Moreo, F.J., Adeli, H. (Eds.), ISBN 978-3-319-18914-7. IWINAC 2015, Elche, 1-5 Junio 2015
Darya Chyzhyk, Manuel Graña
¿Cómo se puede discriminar los pacientes con esquizofrenia mediante imagenes de resonancia magnética funcional?
Poster en Brain Awareness Week, Vitoria, Spain, 20-26 de Marzo, 2014
Darya Chyzhyk, Manuel Graña
Classification of Schizophrenia patients on Lattice Computing resting-state fMRI features [1]
Neurocomputing Volume 151, Part 1, 3 March 2015, Pages 151–160. DOI 10.1016/j.neucom.2014.09.075 JCR 2014 2.083, 2013 2.005 (Q1 CSAI), ISSN 0925-2312
Darya Chyzhyk, Rosalía Dacosta-Aguayo, Maria Mataró, Manuel Graña (pdf)
An active learning approach for stroke lesion segmentation on multimodal MRI data
Neurocomputing, Volume 150, Part A, 20 February 2015, Pages 26-36, ISSN 0925-2312, JCR 2013 2.005 (Q1 CSAI)
Darya Chyzhyk, Marina Graña-Lecuona and Manuel Graña
Late Onset Bipolar Disorder Versus Alzheimer Disease pdf
Innovation in Medicine and Healthcare 2015, Smart Innovation, Systems and Technologies 45: 337-384, Springer International Publishing Switzerland 2016, Y.-W. Chen et al. (eds.), DOI 10.1007/978-3-319-23024-5_34, InMed 2015, Kyoto, Japan, 11-12 September 2015, ISSN 2190-3018 ISSN 2190-3026 (electronic), Smart Innovation, Systems and Technologies, ISBN 978-3-319-23023-8 ISBN 978-3-319-23024-5 (eBook)


Manuel Graña and Darya Chyzhyk
One side lattice memory reduced ordering function allows discrimination in resting state fMRI
Fuzzy Systems (FUZZ-IEEE), 2014 IEEE International Conference on, pp.69-74, doi: 10.1109/FUZZ-IEEE.2014.6891700, ISSN 1098-7584
IEEE World Congress on Computational Intelligence (WCCI), Special Session: Lattice Computing, July 6-11 2014, Beijinn, China, link
Darya Chyzhyk, Manuel Graña, Ann Shinn & Dost Ongur
Discrimination of auditory hallucination sensitive Schizophrenia patients from resting state functional MRI
NeuroGune the second meeting of the Basque research community in Neuroscience, 9 July, 2014, San Sebastian, Spain.
Ponencia: poster
Darya Chyzhyk and Manuel Graña
Findings in resting-state fMRI by differences from K-means clustering
Studies in Health Technology and Informatics, 2014, Volume 207, pp. 300-310, ISBN print 978-1-61499-473-2, ISBN online 978-1-61499-474-9, Pages 428
InMed, 9-11 July, 2014, San-Sebstian, Spain
Alexandre Savio, Darya Chyzhyk, Manuel Graña
Computer Aided Diagnosis of Schizophrenia based on local-activity measures of resting-state fMRI
Hybrid Artificial Intelligence Systems, Volume 8480, pp 1-12, 2014
9th International Conference, HAIS 2014, Salamanca, Spain, June 11-13, 2014. Proceedings.
Print ISBN 978-3-319-07616-4, Online ISBN 978-3-319-07617-1, Publisher Springer International Publishing, DOI 10.1007/978-3-319-07617-1_1
Darya Chyzhyk, Alexandre Savio, Manuel Graña,
Evolutionary ELM wrapper feature selection for Alzheimer's disease CAD on anatomical brain MRI pdf
Neurocomputing, Volume 128, 27 March 2014, Pages 73-80,
ISSN 0925-2312,
JCR (2012) 1.634 (T1, Q2 CSAI)


Darya Chyzhyk and Manuel Graña
Results on a Lattice Computing Based Group Analysis of Schizophrenic Patients on Resting State fMRI
J.M. Ferrandez et al. (Eds.): IWINAC 2013, Part II, LNCS 7931, pp. 131--139. Springer, Heidelberg (2013)
Print ISBN: 978-3-642-38621-3, Online ISBN: 978-3-642-38622-0
ISSN 0302-9743
M. Termenon, D. Chyzhyk, M. Graña, A. Barros-Loscertales, and C. Avila
Cocaine Dependent Classification on MRI Data Extracting Features from Voxel Based Morphometry
J.M. Ferrandez et al. (Eds.): IWINAC 2013, Part II, LNCS 7931, pp. 140--148. Springer, Heidelberg (2013)
Print ISBN: 978-3-642-38621-3, Online ISBN: 978-3-642-38622-0
ISSN 0302-9743
Darya Chyzhyk, Borja Ayerdi, Josu Maiora
Active Learning with Bootstrapped Dendritic Classifier applied to medical image segmentation
Pattern Recognition Letters 34 (2013), pp. 1602-1608
DOI: 10.1016/j.patrec.2013.03.024, ISSN 0167-8655
JCR (2011) 1.034, 5-Year Impact Factor: 1.724 (JRC) (Q3 CSAI)
Darya Chyzhyk, Manuel Graña
Bootstrapped Dendritic Classifiers in MRI analysis for Alzheimer’s Disease recognition. pdf
Advanced Techniques for Knowledge Engineering and Innovative Applications. Editors: Jeffrey W. Tweedale, Lakhmi C. Jain.
Communications in Computer and Information Science Volume 246, 2013, pp 136-142
DOI 10.1007/978-3-642-42017-7_10
Print ISBN 978-3-642-42016-0
Online ISBN 978-3-642-42017-7
Series ISSN 1865-0929
Darya Chyzhyk and Manuel Graña
Discrimination of Resting-State fMRI for Schizophrenia Patients with Lattice Computing Based Features Slides
J.-S. Pan et al. (Eds.): HAIS 2013, LNAI 8073, pp. 482--490. Springer, Heidelberg (2013)
Print ISBN: 978-3-642-40845-8, Online ISBN: 978-3-642-40846-5
ISSN: 0302-9743
DOI 10.1007/978-3-642-40846-5_48

ELM -> Applied Soft Computing


Gerhard X. Ritter, Darya Chyzhyk, Gonzalo Urcid, Manuel Graña
A Novel Lattice Associative Memory Based on Dendritic Computing" draft
Hybrid Artificial Intelligent Systems (HAIS 2012): Special Session on Hybrid Computational Intelligence and Lattice computing for image and signal processing, Salamanca, Spain. March 28-30, 2012. Slides
Published in: HAIS'2012 Proceedings of the 7th international conference on Hybrid Artificial Intelligent Systems - Volume Part II, pp. 491-502, 2012. LNCS 7209
ISBN: 978-3-642-28930-9
Darya Chyzhyk, Alexandre Savio and Manuel Graña
Evolutionary ELM wrapper feature selection for Alzheimer's disease CAD on anatomical brain MRI,
ELM 2012, Singapore, 11-13 December 2012
Darya Chyzhyk
Bootstrapped Dendritic Classifiers for Alzheimer’s Disease classification on MRI features
Advances in Knowledge-Based and Intelligent Information and Engineering Systems.
Frontiers in Artificial Intelligence and Applications (FAIA) series, Vol. 243, pages 2251 - 2258, 2012.
Eds: Manuel Graña, Carlos Toro, Jorge Posada, Robert J. Howlett and Lakhmi C. Jain.
Manuel Graña, Darya Chyzhyk
Hybrid multivariate morphology using lattice auto-associative memories for resting-state fMRI network discovery
HIS 2012, Pune India, 4-7 december 2012 slides
Published in: Hybrid Intelligent Systems (HIS), 2012 12th International Conference on, 537-542, IEEE 2012
DOI: 10.1109/HIS.2012.6421391
Print ISBN: 978-1-4673-5114-0


Darya Chyzhyk, Manuel Graña, Alexandre Savio, Josu Maiora
Hybrid Dendritic Computing with Kernel-LICA applied to Alzheimer’s Disease detection in MRI. PDF
Neurocomputing, 2012, Volumen 75, issue 1, pp. 72-77
ISSN 0925-2312
ISI JCR (2006) 0.860, (2007) 0.865, (2008) 1.234 (2009) 1.440
Darya Chyzhyk, Ann K. Shinn, and Manuel Graña
Exploration of LICA Detections in Resting State fMRI. draft
4th. International work-Conference on the Interplay between Natural and Artificial Computation (IWINAC 2011), La Palma, Canary Islands, Spain. 30 May - 3 June, 2011.
Published in: IWINAC'11 Proceedings of the 4th international conference on Interplay between natural and artificial computation: new challenges on bioinspired applications - Volume Part II, pp.104-111,
ISBN: 978-3-642-21325-0
Darya Chyzhyk, Manuel Graña
Optimal Hyperbox shrinking in Dendritic Computing applied to Alzheimer’s Disease detection in MRI. draft. slides.
Conference on Soft Computing Models in Industrial and Environmental Applications (SOCO 2011), Salamanca, Spain. 6-8th April, 2011.
Advances in Intelligent and Soft Computing, 2011, Volume 87/2011, 543-550, DOI: 10.1007/978-3-642-19644-7_57
Editors: Emilio Corchado, Václav Snášel, Javier Sedano, Aboul Ella Hassanien, José Luis Calvo, Dominik Sle¸zak
Publisher: Springer Berlin / Heidelberg
ISBN: 978-3-642-19643-0


Darya Chyzhyk, Maite Termenon, and Alexandre Savio
A Comparison of VBM results by SPM, ICA and LICA.
Hybrid Artificial Intelligent Systems, Part II, Emilio S. Corchado Rodriguez; Manuel Grana Romay; Alexandre Manhaes Savio (Eds.), (LNCS/LNAI) Vol. 6077, Springer-Verlag Berlin Heidelberg, 2010, pp. 429 - 435 Vol. 2
ISBN 978-3-642-13802-7
Manuel Graña, Darya Chyzhyk, Maite García-Sebastián, Carmen Hernández
Lattice Independent Component Analysis for functional Magnetic Resonance Imaging DRAFT
Information Sciences 181, issue 10, 2011, pp. 1910-1928
Impact factor JCR (2008): 3.095 (2009) 3.291
Alexandre Savio; Maria T Garcia-Sebastian; Darya Chyzhyk; Carmen Hernandez; Manuel Graña; Andone Sistiaga; Adolfo Lopez de Munain; Jorge Villanua
Neurocognitive disorder detection based on Feature Vectors extracted from VBM analysis of structural MRI
Computers in Biology and Medicine 41 (2011), pp. 600-610 DOI ISSN: 0010-4825
ISI Impact JCR (2009) 1.269 (2010) 1.112
Alexandre Savio, Maite García-Sebastián, Andone Sistiaga, Darya Chyzhyk, Esther Fernández, Fermín Moreno, Elsa Fernández, Manuel Graña, Jorge Villanúa, Adolfo López de Munain
Machine Learning Approach for Myotonic Dystrophy Diagnostic Support from MRI
in Juan M. Górriz, Elmar W. Lang and Javier Ramírez (Eds), Recent Advances in Biomedical Signal Processing, 93 - 101
2010 Bentham Science Publishers, ISBN: 978-1-60805-570-8
Chyzhyk, D. and Savio, A.
Feature extraction from structural MRI images based on VBM: data from OASIS database
Technical Report GIC-UPV-EHU-RR-2010-10-14, Grupo de Inteligencia Computacional UPV/EHU, 2010


Darya Chyzhyk
Inferencia en FSL para morfometria basada en vóxel (voxel base morphometry).
III Jornada de Inteligencia Computacional, JIC’09. Servicio editorial de la UPV/EHU, 2009. ISBN 978-84-9860-320-0


Project Reviwer

  • Czech Health Research Council for Ministry of Health of the Czech Republic


  • Neurocomputing 2012
  • Journal of Mathematical Imaging and Vision
  • HAIS 2010
  • An International Journal on Multi-Sensor, Multi-Source Information Fusion
  • Pattern Recognition Letters
  • Neurocomputing 2013
  • Computers in Biology and Medicine


  • Local organizing committee member of the
    • 5th International Conference on Hybrid Artificial Intelligence Systems – HAIS 2010 in San Sebastian (Spain), 23-25 de Junio, 2010.
    • 16th International Conference on Knowledge-Based and Intelligent Information & Engineering Systems – (KES 2012) 10, 11 & 12 September 2012, San Sebastian, Spain.
  • Programme committee member of the
    • CASoN-2011, NWeSP-2011, NaBIC-2011
    • HAIS-2012, NaBIC-2012, CASoN-2012, WeSP-2012, WICT-2012, CISIS 2012 (special session on Intelligent Network Security and Survivability), ELM-2012
    • KES-2013, HAIS-2013, CASoN-2013, ELM-2013, HIS-2013, NaBIC-2013, WeSP-2013, WICT-2013
    • WCCI-2014, KES-2014, HAIS-2014, CASoN-2014, NaBIC-2014, WICT-2014, ISDA-2014


  • University of Florida.
Department of Computer &Information Science & Engineering
Responsable investigator: Professor Gerhard X. Ritter
September 15th – December 15th, 2011
  • Radboud University
Machine Learning Group, Intelligent Systems Institute for Computing and Information Sciences (iCIS) Faculty of Science
Responsable investigator: Professor Tom Heskes
1st of November 2012 – 30th of January 2013

Research projects participation

  • Project Title: Computational Intelligence techniques for brain imaging and the neurosciences
    • Organism: University of Basque Country
    • Reference: MICINN Project, TIN2011-23823
    • Principal Investigator: Prof. Manuel Graña Romay
    • Date: 2011 – 2013.


  • FSL & FreeSurfer Course 2010
Heidelberg, Germany
31 May - 4 June 2010
  • Course on Statistical Parametric Mapping (SPM)
Zurich, Switzerland
16-18 February 2011
  • International Summer Course on Medical Imaging using Bio-inspired and Soft Computing (MIBISOC)
European Centre of Soft Computing, Mieres, Spain
4-8 July 2011

Experiencia en organización de actividades de I+D

  • Special event for children of sensibilization on robotic research (con ASPANOGI), 14 de marzo de 2015, San-Sebstian, España
  • Special event for children of sensibilization on robotic research, 11 de noviembre de 2014, San-Sebstian, España
  • XII Semana de la Ciencia 2012, Stand: Las conexiones de tu cerebro
  • X Semana de la Ciencia 2010, Stand: Mundo virtual
  • IX Semana de la Ciencia 2009, Stand: Las conexiones de tu cerebro

Congress of interest

  • HAIS 2012, Salamanca, Spain, March 28th-30th, 2012.

  • ISBI 2012, 2-5 May, Barcelona, Spain.

  • ESANN 2012, Bruges, Belgium, 25 to 27 April 2012 - 20th anniversary !

  • Neuroinformatics 2012, Munich, Germany, September 10-12 deadline February - April, 2012

  • MICCAI 2013

16th International Conference on Medical Image Computing and Computer-Assisted Intervention 21 September 2013 - 26 September 2013 Nagoya, Japan


  • ICIP

20th IEEE International Conference on Image Processing ICIP 16 September 2013 - 18 September 2013 Melbourne, VIC, Australia


TFMs resting-state-fmri-templates FSL:brainmap+rsns icatb-discuss

  • Multimodal data, controls, here

Data base



  • Infornacion general

Ayudas postdoctorales UPV

Estado burocrático de la tesis

Director - Manuel Graña Romay
beca concedida desde agosto 2009
Diploma de Estudios Avanzados en Inteligencia Computacional (DEA), 9 de febrero de 2010
Estudio de técnicas de análisis de imagen con aplicación a la morfometría cerebral


Friday sessions

Friday sessions

tareas pendientes

1 -Reformato de imagenes[2], funcionales, fMRI

  • coger imágenes del administrador de archivos de la cuenta de visitantes del groupware.
  • usar MRIcron[3] para pasar de formato DICOM a NIfTI (imagen final 4D)
  • ¿Existe una imagen estructural(MRI (T1))? Si existe convertirla en formato NIfTI (imagen final 3D)
  • Comprobar que se puede trabajar con el SPM5[4] y las imágenes NIfTI que hemos generado.

2 -Crear una variable en Matlab que contenga todas las imágenes de fMRI para aplicar nuestros algoritmos de análisis.

  • Funciones a utilizar (dicominfo y dicomread)


  • “Open with” (user defined command) Ubuntu 12.10 Tweak - file manager
  • NIF de la Uni Q4818001B
  • fslorient -setqform -3 0 0 90 0 3 0 -126 0 0 3 -72 0 0 0 1 sub_3mm_twoseeds_CSF_LHG_xroiregress_sm3.nii
 fslorient -setsform -3 0 0 90 0 3 0 -126 0 0 3 -72 0 0 0 1 sub_3mm_twoseeds_CSF_LHG_xroiregress_sm3.nii
  • fsl install debian

sudo apt-get install fsl-complete

nano .bashrc 

sudo apt-get install ssh vim gedit-plugins

  • not found fsl function




+ LabNic, geneva

  • Thomas H Mareci.Frank J Bova.