2.
Cartagena, Manuel Eduardo Martinez; Suarez, Lucia; Ontoria, Aitor; Benitez, Francisca J.; Rezabal, Elixabete; Orellano, María Soledad; Calderón, Marcelo; Huck‐Iriart, Cristián; Picco, Agustin S.; Picchio, Matias L.; Beloqui, Ana
Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis Journal Article
In: Advanced Materials, 2025, ISSN: 1521-4095.
Abstract | Links | BibTeX | Tags: EJ1584, isom-app, SUS-KT, Sus-KT
@article{MartinezCartagena2025,
title = {Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis},
author = {Manuel Eduardo Martinez Cartagena and Lucia Suarez and Aitor Ontoria and Francisca J. Benitez and Elixabete Rezabal and María Soledad Orellano and Marcelo Calderón and Cristián Huck‐Iriart and Agustin S. Picco and Matias L. Picchio and Ana Beloqui},
doi = {10.1002/adma.202517014},
issn = {1521-4095},
year = {2025},
date = {2025-12-24},
urldate = {2025-12-24},
journal = {Advanced Materials},
publisher = {Wiley},
abstract = {<jats:title>ABSTRACT</jats:title>
<jats:p>The development of soft hybrid materials that combine structural integrity, biocompatibility, and catalytic function is a central challenge in advanced biocatalysis. Here, we introduce eutectozymes, enzyme‐loaded eutectogels built from natural hydrophobic deep eutectic solvents (HES) and stabilized through a dual supramolecular polymeric network. This unique architecture not only preserves the conformational integrity of enzymes but also creates confined microcavities acting as protective microreactors, thereby enhancing their stability and substrate affinity. Eutectozymes exhibit remarkable resilience under harsh operational conditions, including high temperatures, extreme pH, and organic solvents, while maintaining high catalytic efficiency and reusability. Their versatility is further demonstrated in environmental remediation, achieving over 90% degradation of recalcitrant dyes, and in antimicrobial applications against resistant bacterial strains. By synergistically merging the stabilizing properties of HES with robust gel matrices, eutectozymes establish a transformative platform for heterogeneous biocatalysis, opening new avenues in biotechnology, bioelectronics, and environmental technologies.</jats:p>},
keywords = {EJ1584, isom-app, SUS-KT, Sus-KT},
pubstate = {published},
tppubtype = {article}
}
<jats:title>ABSTRACT</jats:title>
<jats:p>The development of soft hybrid materials that combine structural integrity, biocompatibility, and catalytic function is a central challenge in advanced biocatalysis. Here, we introduce eutectozymes, enzyme‐loaded eutectogels built from natural hydrophobic deep eutectic solvents (HES) and stabilized through a dual supramolecular polymeric network. This unique architecture not only preserves the conformational integrity of enzymes but also creates confined microcavities acting as protective microreactors, thereby enhancing their stability and substrate affinity. Eutectozymes exhibit remarkable resilience under harsh operational conditions, including high temperatures, extreme pH, and organic solvents, while maintaining high catalytic efficiency and reusability. Their versatility is further demonstrated in environmental remediation, achieving over 90% degradation of recalcitrant dyes, and in antimicrobial applications against resistant bacterial strains. By synergistically merging the stabilizing properties of HES with robust gel matrices, eutectozymes establish a transformative platform for heterogeneous biocatalysis, opening new avenues in biotechnology, bioelectronics, and environmental technologies.</jats:p>
<jats:p>The development of soft hybrid materials that combine structural integrity, biocompatibility, and catalytic function is a central challenge in advanced biocatalysis. Here, we introduce eutectozymes, enzyme‐loaded eutectogels built from natural hydrophobic deep eutectic solvents (HES) and stabilized through a dual supramolecular polymeric network. This unique architecture not only preserves the conformational integrity of enzymes but also creates confined microcavities acting as protective microreactors, thereby enhancing their stability and substrate affinity. Eutectozymes exhibit remarkable resilience under harsh operational conditions, including high temperatures, extreme pH, and organic solvents, while maintaining high catalytic efficiency and reusability. Their versatility is further demonstrated in environmental remediation, achieving over 90% degradation of recalcitrant dyes, and in antimicrobial applications against resistant bacterial strains. By synergistically merging the stabilizing properties of HES with robust gel matrices, eutectozymes establish a transformative platform for heterogeneous biocatalysis, opening new avenues in biotechnology, bioelectronics, and environmental technologies.</jats:p>
1.
Verdugo, Marta Costa; Sierri, Giulia; Hernandez-Fernandez, Laura; Formoso, Elena; Miranda, José I.; Sica, Francesco Saverio; Orrego, Alejandro H.; González, Alba; Rezabal, Elixabete; Re, Francesca; Salassa, Luca
Choline–geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs Journal Article
In: Chem. Commun., vol. 61, no. 65, pp. 12167–12170, 2025, ISSN: 1364-548X.
Abstract | Links | BibTeX | Tags: EJ1584, isom-app, SUS-KT
@article{Verdugo2025,
title = {Choline–geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs},
author = {Marta Costa Verdugo and Giulia Sierri and Laura Hernandez-Fernandez and Elena Formoso and José I. Miranda and Francesco Saverio Sica and Alejandro H. Orrego and Alba González and Elixabete Rezabal and Francesca Re and Luca Salassa},
doi = {10.1039/d5cc02226f},
issn = {1364-548X},
year = {2025},
date = {2025-08-07},
urldate = {2025-08-07},
journal = {Chem. Commun.},
volume = {61},
number = {65},
pages = {12167--12170},
publisher = {Royal Society of Chemistry (RSC)},
abstract = {<jats:p>CAGE IL formulations significantly enhance the potency of platinum-based drugs in glioblastoma cells.</jats:p>},
keywords = {EJ1584, isom-app, SUS-KT},
pubstate = {published},
tppubtype = {article}
}
<jats:p>CAGE IL formulations significantly enhance the potency of platinum-based drugs in glioblastoma cells.</jats:p>