2016
Szot P, Franklin A, Miguelez C, Wang Y, Vidaurrazaga I, Ugedo L, Sikkema C, Wilkinson CW, Raskind MA. Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine. Neuropharmacology. 2016 Feb;101:76-86. doi: 10.1016/j.neuropharm.2015.09.003. Epub 2015 Sep 8. PMID: 26362360; PMCID: PMC4782767.
Sagarduy A, Llorente J, Miguelez C, Morera-Herreras T, Ruiz-Ortega JA, Ugedo L. Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors. Exp Neurol. 2016 Mar;277:35-45. doi: 10.1016/j.expneurol.2015.12.005. Epub 2015 Dec 11. PMID: 26687972.
Aristieta A, Ruiz-Ortega JA, Miguelez C, Morera-Herreras T, Ugedo L. Chronic L-DOPA administration increases the firing rate but does not reverse enhanced slow frequency oscillatory activity and synchronization in substantia nigra pars reticulata neurons from 6-hydroxydopamine-lesioned rats. Neurobiol Dis. 2016 May;89:88-100. doi: 10.1016/j.nbd.2016.02.003. Epub 2016 Feb 4. PMID: 26852950.
Miguelez C, Navailles S, De Deurwaerdère P, Ugedo L. The acute and long-term L-DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6-OHDA lesioned rats. Br J Pharmacol. 2016 Jul;173(13):2135-46. doi: 10.1111/bph.13447. Epub 2016 Mar 8. PMID: 26805402; PMCID: PMC4908202.
Miguelez C, Navailles S, Delaville C, Marquis L, Lagière M, Benazzouz A, Ugedo L, De Deurwaerdère P. L-DOPA elicits non-vesicular releases of serotonin and dopamine in hemiparkinsonian rats in vivo. Eur Neuropsychopharmacol. 2016 Aug;26(8):1297-309. doi: 10.1016/j.euroneuro.2016.05.004. Epub 2016 May 24. PMID: 27234917.
2017
Borges G, Miguelez C, Neto F, Mico JA, Ugedo L, Berrocoso E. Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats. Int J Neuropsychopharmacol. 2017 Jun 1;20(6):463. doi: 10.1093/ijnp/pyx005. PMID: 28158734; PMCID: PMC5458337.
Miguelez C, Benazzouz A, Ugedo L, De Deurwaerdère P. Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications. Front Cell Neurosci. 2017 Sep 12;11:274. doi: 10.3389/fncel.2017.00274. PMID: 28955204; PMCID: PMC5600927.
2018
Chazalon M, Paredes-Rodriguez E, Morin S, Martinez A, Cristóvão-Ferreira S, Vaz S, Sebastiao A, Panatier A, Boué-Grabot E, Miguelez C, Baufreton J. GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents. Cell Rep. 2018 May 8;23(6):1678-1690. doi: 10.1016/j.celrep.2018.04.014. PMID: 29742425.
Froux L, Le Bon-Jego M, Miguelez C, Normand E, Morin S, Fioramonti S, Barresi M, Frick A, Baufreton J, Taupignon A. D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus. Sci Rep. 2018 Jun 11;8(1):8858. doi: 10.1038/s41598-018-27195-6. PMID: 29891970; PMCID: PMC5995923.
2019
Murueta-Goyena A, Morera-Herreras T, Miguelez C, Gutiérrez-Ceballos A, Ugedo L, Lafuente JV, Bengoetxea H. Effects of adult enriched environment on cognition, hippocampal-prefrontal plasticity and NMDAR subunit expression in MK-801-induced schizophrenia model. Eur Neuropsychopharmacol. 2019 May;29(5):590-600. doi: 10.1016/j.euroneuro.2019.03.009. Epub 2019 Mar 26. PMID: 30926324.
Vegas-Suarez S, Paredes-Rodriguez E, Aristieta A, Lafuente JV, Miguelez C, Ugedo L. Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia. Int Rev Neurobiol. 2019;146:259-279. doi: 10.1016/bs.irn.2019.06.013. Epub 2019 Jul 18. PMID: 31349930.
Mallet N, Delgado L, Chazalon M, Miguelez C, Baufreton J. Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum. Cells. 2019 Aug 29;8(9):1005. doi: 10.3390/cells8091005. PMID: 31470672; PMCID: PMC6769933.
Aristieta A, Ruiz-Ortega JA, Morera-Herreras T, Miguelez C, Ugedo L. Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats. Exp Neurol. 2019 Dec;322:113036. doi: 10.1016/j.expneurol.2019.113036. Epub 2019 Aug 16. PMID: 31425688.
2020
Paredes-Rodriguez E, Vegas-Suarez S, Morera-Herreras T, De Deurwaerdere P, Miguelez C. The Noradrenergic System in Parkinson's Disease. Front Pharmacol. 2020 Apr 8;11:435. doi: 10.3389/fphar.2020.00435. PMID: 32322208; PMCID: PMC7157437.
Miguelez C, De Deurwaerdère P, Sgambato V. Editorial: Non-Dopaminergic Systems in Parkinson's Disease. Front Pharmacol. 2020 Sep 11;11:593822. doi: 10.3389/fphar.2020.593822. PMID: 33013427; PMCID: PMC7516253.
Vegas-Suárez S, Pisanò CA, Requejo C, Bengoetxea H, Lafuente JV, Morari M, Miguelez C, Ugedo L. 6-Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata. Br J Pharmacol. 2020 Sep;177(17):3957-3974. doi: 10.1111/bph.15145. Epub 2020 Jul 6. PMID: 32464686; PMCID: PMC7429490.
Soria FN, Miguelez C, Peñagarikano O, Tønnesen J. Current Techniques for Investigating the Brain Extracellular Space. Front Neurosci. 2020 Oct 14;14:570750. doi: 10.3389/fnins.2020.570750. PMID: 33177979; PMCID: PMC7591815.
Requejo C, López-de-Ipiña K, Ruiz-Ortega JÁ, Fernández E, Calvo PM, Morera-Herreras T, Miguelez C, Cardona-Grifoll L, Cepeda H, Ugedo L, Lafuente JV. Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson's Disease: Exploring Prodromal Biomarkers. Front Neurosci. 2020 Oct 14;14:590029. doi: 10.3389/fnins.2020.590029. PMID: 33154717; PMCID: PMC7591774.
2021
Vegas-Suárez S, Aristieta A, Requejo C, Bengoetxea H, Lafuente JV, Miguelez C, Ugedo L. The effect of 5-HT1A receptor agonists on the entopeduncular nucleus is modified in 6-hydroxydopamine-lesioned rats. Br J Pharmacol. 2021 Jun;178(12):2516-2532. doi: 10.1111/bph.15437. Epub 2021 May 6. PMID: 33686657; PMCID: PMC8252460.
Mora-Jimenez L, Valencia M, Sanchez-Carpintero R, Tønnesen J, Fadila S, Rubinstein M, Gonzalez-Aparicio M, Bunuales M, Fernandez-Pierola E, Nicolas MJ, Puerta E, Miguelez C, Minguez PG, Lumbreras S, Gonzalez-Aseguinolaza G, Ricobaraza A, Hernandez-Alcoceba R. Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations. Mol Ther Nucleic Acids. 2021 Aug 19;25:585-602. doi: 10.1016/j.omtn.2021.08.003. PMID: 34589280; PMCID: PMC8463324.
Elexpe A, Nieto N, Fernández-Cuétara C, Domínguez-Fernández C, Morera-Herreras T, Torrecilla M, Miguélez C, Laso A, Ochoa E, Bailen M, González-Coloma A, Angulo-Barturen I, Astigarraga E, Barreda-Gómez G. Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds. Membranes (Basel). 2021 Nov 29;11(12):943. doi: 10.3390/membranes11120943. PMID: 34940444; PMCID: PMC8705675.
Rivera A, Suárez-Boomgaard D, Miguelez C, Valderrama-Carvajal A, Baufreton J, Shumilov K, Taupignon A, Gago B, Real MÁ. Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum. Cells. 2021 Dec 23;11(1):31. doi: 10.3390/cells11010031. PMID: 35011592; PMCID: PMC8750869.
2022
Ballesteros-Peña S, Fernández-Aedo I, Vallejo-De la Hoz G, Tønnesen J, Miguelez C. Identification of potentially irritating intravenous medications. Enferm Intensiva (Engl Ed). 2022 Jul-Sep;33(3):132-140. doi: 10.1016/j.enfie.2021.05.003. Epub 2022 Aug 5. PMID: 35941074.
Vegas-Suárez S, Morera-Herreras T, Requejo C, Lafuente JV, Moratalla R, Miguélez C, Ugedo L. Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation. Front Pharmacol. 2022 Aug 30;13:953652. doi: 10.3389/fphar.2022.953652. PMID: 36133803; PMCID: PMC9483552.
2023
Domínguez-Fernández C, Egiguren-Ortiz J, Razquin J, Gómez-Galán M, De Las Heras-García L, Paredes-Rodríguez E, Astigarraga E, Miguélez C, Barreda-Gómez G. Review of Technological Challenges in Personalised Medicine and Early Diagnosis of Neurodegenerative Disorders. Int J Mol Sci. 2023 Feb 7;24(4):3321. doi: 10.3390/ijms24043321. PMID: 36834733; PMCID: PMC9968142.
Vaquero-Rodríguez A, Razquin J, Zubelzu M, Bidgood R, Bengoetxea H, Miguelez C, Morera-Herreras T, Ruiz-Ortega JA, Lafuente JV, Ortuzar N. Efficacy of invasive and non-invasive methods for the treatment of Parkinson's disease: Nanodelivery and enriched environment. Int Rev Neurobiol. 2023;172:103-143. doi: 10.1016/bs.irn.2023.05.010. Epub 2023 Jun 8. PMID: 37833010.
Mariscal P, Bravo L, Llorca-Torralba M, Razquin J, Miguelez C, Suárez-Pereira I, Berrocoso E. Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice. Biol Sex Differ. 2023 Sep 28;14(1):64. doi: 10.1186/s13293-023-00550-7. PMID: 37770907; PMCID: PMC10540344.
Delgado-Zabalza L, Mallet NP, Glangetas C, Dabee G, Garret M, Miguelez C, Baufreton J. Targeting parvalbumin-expressing neurons in the substantia nigra pars reticulata restores motor function in parkinsonian mice. Cell Rep. 2023 Oct 31;42(10):113287. doi: 10.1016/j.celrep.2023.113287. Epub 2023 Oct 14. PMID: 37843977.
2024
Hernandez-Suarez L, Diez-Martin E, Egiguren-Ortiz J, Fernandez R, Etxebarria A, Astigarraga E, Miguelez C, Ramirez-Garcia A, Barreda-Gómez G. Serological Antibodies against Kidney, Liver, and Spleen Membrane Antigens as Potential Biomarkers in Patients with Immune Disorders. Int J Mol Sci. 2024 Feb 7;25(4):2025. doi: 10.3390/ijms25042025. PMID: 38396703; PMCID: PMC10888476.
Kelberman MA, Rodberg E, Arabzadeh E, Bair-Marshall CJ, Berridge CW, Berrocoso E, Breton-Provencher V, Chandler DJ, Che A, Davy O, Devilbiss DM, Downs AM, Drummond G, Dvorkin R, Fazlali Z, Froemke RC, Glennon E, Gold JI, Ito H, Jiang X, Johansen JP, Kaye AP, Kim JR, Kuo CC, Liu RJ, Liu Y, Llorca-Torralba M, McCall JG, McElligott ZA, McKinney AM, Miguelez C, Min MY, Nowlan AC, Omrani M, Poe GR, Pickering AE, Ranjbar-Slamloo Y, Razquin J, Rodenkirch C, Sales AC, Satyasambit R, Shea SD, Sur M, Tkaczynski JA, Torres-Sanchez S, Uematsu A, Vazquez CR, Vreven A, Wang Q, Waterhouse BD, Yang HW, Yang JH, Zhao L, Zouridis IS, Weinshenker D, Vazey E, Totah NK. Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors. bioRxiv [Preprint]. 2024 Oct 16:2024.10.14.618224. doi: 10.1101/2024.10.14.618224. PMID: 39464004; PMCID: PMC11507722.
2025
Vaquero-Rodríguez A, Razquin J, Murueta-Goyena A, Miguelez C, Ruíz-Ortega JÁ, Lafuente JV, Bengoetxea H, Ortuzar N. Temporal progression of pathological features in an α-synuclein overexpression model of Parkinson's disease. Brain Struct Funct. 2025 Jun 9;230(6):91. doi: 10.1007/s00429-025-02959-9. PMID: 40488786; PMCID: PMC12149260.
Murueta-Goyena A, Del Pino R, Carmona-Abellán M, Tijero B, Ruiz-Lopez M, Acera M, Morera-Herreras T, Miguelez C, Sáez-Atxukarro O, Fernández-Valle T, Gabilondo I, Gómez-Esteban JC. Effect of sex on the progression of non-motor symptoms in Parkinson's disease: A registry-based cohort study. Neurologia (Engl Ed). 2025 Sep;40(7):620-629. doi: 10.1016/j.nrleng.2025.07.006. PMID: 40903147.
2026
Huergo C, de Las Heras-García L, Razquin J, Rueda Y, Miguélez C, Fernández JA. Characterization of the Lipidome of Neurons in Mouse Brain Nuclei Using Imaging Mass Spectrometry. Anal Chem. 2026 Jan 27;98(3):2579-2588. doi: 10.1021/acs.analchem.5c08016. Epub 2026 Jan 12. PMID: 41527248; PMCID: PMC12856826.