Asymmetric Cyanation of alpha-Ketiminophosphonates Catalyzed by Cinchona Alkaloids: Enantioselective Synthesis of Tetrasubstituted alpha-Aminophosphonic Acid Derivatives from Trisubstituted alpha-Aminophosphonates
- Egileak:
- Javier Vicario, José María Ezpeleta, Francisco Palacios
- Urtea:
- 2012
- Non argitaratua:
- Advanced Synthesis & Catalysis
- Liburukia:
- 354
- Hasierako orria - Amaierako orria:
- 2641 - 2647
- Deskribapena:
-
An enantioselective synthesis of tetrasubstituted α-phosphono-α-amino nitriles through asymmetric cyanation of α-ketiminophosphonates catalyzed by Cinchona alkaloids is reported. α-Ketiminophosphonates are generated, in a very efficient synthetic protocol, by oxidation of trisubstituted α-aminophosphonates.