Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of α-aminophosphonic acid derivatives
- Egileak:
- Francisco Palacios, Tomasz K. Olszewski, Javier Vicario
- Urtea:
- 2010
- Aldizkaria:
- Organic & Biomolecular Chemistry
- Liburukia:
- 8
- Hasierako orria - Amaierako orria:
- 4255 - 4258
- Deskribapena:
-
Efficient synthesis of α-aminophosphonic acid derivatives is achieved, the key step being a diastereoselective hydrophosphonylation of N-diphenylphosphinyl imines using a readily available chiral cyclic (R,R)-TADDOL-phosphite derived from inexpensive natural tartaric acid.