Brönsted-Acid-Catalyzed Asymmetric Three-Component Reaction of Amines, Aldehydes, and Pyruvate Derivatives. Enantioselective Synthesis of Highly Functionalized γ-Lactam Derivatives
- Egileak:
- Xabier del Corte, Aitor Maestro, Javier Vicario , Edorta Martinez de Marigorta, and Francisco Palacios
- Urtea:
- 2018
- Aldizkaria:
- Organic Letters
- Liburukia:
- 20
- Hasierako orria - Amaierako orria:
- 317 - 320
- Deskribapena:
-
Chiral phosphoric acids are efficient organocatalysts for the asymmetric three-component reaction of amines, aldehydes, and pyruvate derivatives. Simultaneous condensation of amines with both carbonylic compounds followed by a hydrogen bonding activated nucleophilic addition of enamines to imines affords densely functionalized enantioenriched 1,5-dihydro-2H-pyrrol-2-ones. These substrates can be used in subsequent diastereoselective transformations to afford enantiopure γ-lactam derivatives