Signaling Lab Research Group

• Jon Luzuriaga, Nerea García-Urkia, Jone Salvador-Moya, Beatriz Pardo-Rodríguez, Iker Etxebarria, Francisco-Javier Fernandez-San-Argimiro, Beatriz Olalde, Fernando Unda, Jose Ramon Pineda, Iratxe Madarieta, Gaskon Ibarretxe  Changes in osteogenesis by human dental pulp stem cells on porcine decellularised adipose tissue solid foams of different porosity European Cells and Materials IF: 3.1 (Q1),  2023;  46,  119 - 137 -  1473-2262
• Niechi I, Pineda JR  Editorial: Tumor microenvironment in primary brain cancers. Front Oncol. IF: 4.7 (Q1),  2023;  13,  1 - 2 -  2234-943X
• Uribe-Etxebarria V, Pineda JR, García-Gallastegi P, Agliano A, Unda F, Ibarretxe G.  Notch and Wnt Signaling Modulation to Enhance DPSC Stemness and Therapeutic Potential. Int J Mol Sci. IF: 5.6 (Q1),  2023;  24,  1 - 14 -  1422-0067
• Descarpentrie J, Araúzo-Bravo MJ, He Z, François A, González Á, Garcia-Gallastegi P, Badiola I, Evrard S, Pernot S, Creemers JWM, Khatib AM.  Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors. Cancers IF: 6.5 (Q1),  2022;  14,  2072-6694
• Garcia-Urkia N, Luzuriaga J, Uribe-Etxebarria V, Irastorza I, Fernandez-San-Argimiro FJ, Olalde B, Briz N, Unda F, Ibarretxe G, Madarieta I, Pineda JR.  Enhanced Adipogenic Differentiation of Human Dental Pulp Stem Cells in Enzymatically Decellularized Adipose Tissue Solid Foams. Biology IF: 5.168 (Q1),  2022;  11,  1 - 19 -  2079-7737
• Romayor I, Herrera L, Burón M, Martin-Inaraja M, Prieto L, Etxaniz J, Inglés-Ferrándiz M, Pineda JR, Eguizabal C.  A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells. Biomedicines IF: 4.75 (Q2),  2022;  10,  1 - 19 -  2227-9059
• François A, Descarpentrie J, Badiola I, Siegfried G, Evrard S, Pernot S, Khatib AM.  Reprogramming immune cells activity by furin-like enzymes as emerging strategy for enhanced immunotherapy in cancer Br J Cancer. IF: 764 (Q1),  2022;  1532-1827
• Velado-Eguskiza A, Gomez-Santos L, Badiola I, Sáez FJ, Alonso E.  Testicular Germ Cell Tumours and Proprotein Convertases 2022
• Pineda JR*, Polo Y, Pardo-Rodríguez B, Luzuriaga J, Uribe-Etxebarria V, García-Gallastegui P, Sarasua JR, Larrañaga A*, Ibarretxe G*.  In vitro preparation of human Dental Pulp Stem Cell grafts with biodegradable polymer scaffolds for nerve tissue engineering. Methods Cell Biol.,  2022;  147 - 167 -  0091-679X
• Jon Luzuriaga, Yurena Polo, Oier Pastor-Alonso, Beatriz Pardo-Rodriguez, Aitor Larrañaga, Fernando Unda, Jose Ramon Sarasua, Jose Ramon Pineda, Gaskon Ibarretxe.  Advances and perspectives in dental pulp stem cell based neuroregeneration therapies. International Journal of Molecular Sciences IF: 5.923 (Q1),  2021;  22,  1 - 21 -  1422-0067
• Gómez-Santos,L., Alonso,E., Crende,O., Ibarretxe,G., Madrid,J. F., Sáez,F. J.  Identification of sugar moieties in chief cells of the rat fundic gastric glands 2021;  96,  221 - 230 -  1447-6959
• S. Olaechea-Lázaro, I. García-Santisteban, JR. Pineda, I. Badiola, S. Alonso, JR. Bilbao, N. Fernandez-Jimenez  shinyCurves, a shiny web application to analyse multisource qPCR amplification data: a COVID 19 case study 2021;  22,  1 - 6 -  1471-2105
• Ichinose M, Suzuki N, Wang T, Wright JA, Lannagan TRM, Vrbanac L, Kobayashi H, Gieniec KA, Ng JQ, Hayakawa Y, García-Gallastegui P, Monsalve EM, Bauer SR, Laborda J, García-Ramírez JJ, Ibarretxe G, Worthley DL, Woods SL.  Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development. Am J Physiol Gastrointest Liver Physiol. IF: 4.8 (Q1),  2021;  4,  506 - 520 -  2051-817X
• Y Polo, J Luzuriaga, J Iturri, I Irastorza, J L Toca-Herrera, G Ibarretxe, F Unda, J R Sarasua, J R Pineda*, A Larrañaga*  Nanostructured scaffolds based on Bioresorbable polymers and Graphene oxide induce the aligned migration and accelerate the neuronal differentiation of neural stem cells Nanomedicine IF: 6.458 (Q1),  2021;  31,  1 - 16 -  1549-9642 (Electronic)
• S. Olaechea-Lázaro, I. García-Santisteban, JR. Pineda, I. Badiola, S. Alonso, JR. Bilbao, N. Fernandez-Jimenez  shinyCurves, a shiny web application to analyse multisource qPCR amplification data: a COVID 19 case study BMC Bioinformatics. IF: 3.2 (Q2),  2021;  22,  1471-2105
• Jose R. Pineda, Iker Badiola and Gaskon Ibarretxe  Stem and Cancer Stem Cell Identities, Cellular Markers, Niche Environment and Response to Treatments to Unravel New Therapeutic Targets Biology IF: 5.079 (Q1),  2021;  10,  1 - 2 -  2079-7737
• Verónica Uribe-Etxebarria, Patricia García-Gallastegui, Miguel Pérez-Garrastachu, María Casado-Andrés, Igor Irastorza, Fernando Unda, Gaskon Ibarretxe, Nerea Subirán  Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells. Cells,  2020;  9,  1 - 21 -  2073-4409 (Electronic)
• Laura Gómez-Santos, Edurne Alonso, Olatz Crende, Gaskon Ibarretxe, Juan Francisco Madrid, Francisco José Sáez  Identification of sugar moieties in chief cells of the rat fundic gastric glands. Anatomical science international,  2020;  144-6959
• Irene Romayor, Iker Badiola, Elvira Olaso  Inhibition of DDR1 reduces invasive features of human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells Cell Adh Migr.,  2020;  1,  69 - 81 -  1933-6926 (Electronic)
• O. Crende, P. García-Gallastegui, J. Luzuriaga, I. Badiola, C. de la Hoz, F. Unda, G. Ibarretxe*, and J.R. Pineda*  Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp Biology IF: 5.079 (Q1),  2020;  9,  1 - 26 -  2079-7737
• Jon Luzuriaga, Jon Irurzun, Igor Irastorza, Fernando Unda, Gaskon Ibarretxe*, Jose R Pineda*  Vasculogenesis from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media Biomedicines IF: 6.081 (Q1),  2020;  8,  1 - 19 -  2227-9059
• Jon Luzuriaga, Jose Ramon Pineda*, Igor Irastorza, Veronica Uribe-Etxebarria, Patricia García-Gallastegui, Juan Manuel Encinas, Pablo Chamero, Fernando Unda, Gaskon Ibarretxe*  BDNF and NT3 Reprogram Human Ectomesenchymal Dental Pulp Stem Cells to Neurogenic and Gliogenic Neural Crest Progenitors Cultured in Serum-Free Medium Cellular Physiology and Biochemistry IF: 5.5 (Q1),  2019;  52,  1361 - 1380 -  1421-9778 (Electronic)
• Jon Luzuriaga, Oier Pastor-Alonso, Juan Manuel Encinas, Fernando Unda, Gaskon Ibarretxe*, Jose Ramon Pineda*  Human Dental Pulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain Frontiers in Physiology IF: 3.367 (Q1),  2019;  10,  1 - 10 -  1664-042X
• I Irastorza, J Luzuriaga, R Martinez-Conde, G Ibarretxe, F Unda  Adhesion, integration and osteogenesis of human dental pulp stem cells on biomimetic implant surfaces combined with plasma derived products European cells & materials,  2019;  38,  201 - 214 -  1473-2262 (Electronic)
• Marquez J, Kratchmarova I, Akimov V, Unda F, Ibarretxe G, Clerigué AS, Osinalde N, Badiola I.  NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells. Oncology Reports IF: 3.041,  2019;  41,  742 - 752
• Aitor Benedicto, Alba Herrero, Irene Romayor, Joana Marquez, Bård Smedsrød, Elvira Olaso, Beatriz Arteta  Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses Sci Rep,  2019;  1,  2045-2322 (Electronic)
• Fernandez-Piñeiro I, Pensado A, Badiola I, Sanchez A.  Development and characterisation of chondroitin sulfate- and hyaluronic acid-incorporated sorbitan ester nanoparticles as gene delivery systems. European Journal of pharmaceutics and biopharmaceutics. IF: 4.708 (Q1),  2018;  125,  85 - 94
• Marquez J, Fernandez-Piñeiro I, Araúzo-Bravo MJ, Poschmann G, Stühler K, Khatib AM, Sanchez A, Unda F, Ibarretxe G, Bernales I, Badiola I  Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine colon cancer metastasis to the liver International Journal of Cancer IF: 7.36 (Q1),  2018;  143,  709 - 719
• Fernandez-Piñeiro I, Alvarez-Trabado J, Márquez J, Badiola I, Sanchez A.  Xanthan gum-functionalised span nanoparticles for gene targeting to endothelial cells. Colloids and surfaces. B, Biointerfaces IF: 3.973 (Q1),  2018;  170,  411 - 420
• Francisco José Sáez Crespo, Iker Badiola Etxaburu  Giza Histologiari buruzko eskuliburua Odontologiako ikasleentzat 2018;  978-84-9082-807-6
• Iker Badiola Etxaburu, Edurne Alonso Arana  Giza Histologia Medikoa UEU- UPV/EHU,  2018;  978-84-9082-976-9
• Ma J, Evrard S, Badiola I, Siegfried G, Khatib AM.  Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). European Journal of Cell Biology IF: 3.93,  2017;  96,  457 - 468
• Fernandez-Piñeiro I, Badiola I, Sanchez A.  Nanocarriers for microRNA delivery in cancer medicine. Biotechnology advances. IF: 11.452 (Q1),  2017;  35,  350 - 360
• Francisco José Sáez Crespo, Iker Badiola Etxaburu  Manual de Histología Humana para estudiantes de odontología UPV/EHU,  2017;  978-84-9082-739-0
• Naso LG, Badiola I, Marquez Clavijo J, Valcarcel M, Salado C, Ferrer EG, Williams PAM.  Inhibition of the metastatic progression of breast and colorectal cancer in vitro and in vivo in murine model by the oxidovanadium(IV) complex with luteolin. Biorganic Medical Chemistry,  2016;  22,  6004 - 6011
• Badiola I, Santaolalla F, Garcia-Gallastegui P, Ana SD, Unda F, Ibarretxe G.  Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing. Ageing Research Reviews IF: 7.526 (Q1),  2015;  23,  125 - 138
• Iker Badiola Etxaburu, Edurne Alonso Arana  Giza Histologia Orokorra UEU- UPV/EHU,  2015;  978-84-8438-565-3
• García-Gallastegui P, Ibarretxe G, Garcia-Ramírez JJ, Baladrón V, Aurrekoetxea M, Nueda ML, Naranjo AI, Santaolalla F, Sánchez-del Rey A, Laborda J, Unda F.  DLK1 regulates branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling. Biology of the Cell.,  2014;  106(8):,  237 - 253
• Ibarretxe G, Aurrekoetxea M, Crende O, Badiola I, Jimenez-Rojo L, Nakamura T, Yamada Y, Unda F.  Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development. Cell and Tissue Research. IF: 3.677,  2012;  35,  195 - 107
• Ibarretxe G., Alvarez A, Cañavate ML, Hilario E, Aurrekoetxea M, Unda F  Cell reprogramming, IPS limitations and overcoming strategies in dental bioengineering Stem Cells International,  2012;  1687-966X
• Ibarretxe G, Crende O, Aurrekoetxea M, García V, Etxaniz J, Unda F  Neural crest Stem cells from dental tissues: A new hope for dental and neural tissue regeneration Stem Cells International,  2012;  1687-966X
• Ibarretxe G, Aurrekoetxea M, Crende O, Jiménez-Rojo L, Nakamura T, Badiola I, Yamada I, Unda F  Epiprofin/Sp6 enhances mesenchymal Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development Cell & Tissue Research,  2012;  350 (1),  95 - 107
• Aurrekoetxea M, López J, García-Gallastegui P, Ibarretxe G, Unda F  Enhanced Wnt/b-catenin signaling during tooth morphogenesis impedes cell differentiation, and leads to alterations in the structure and mineralization of the adult tooth Biology of the Cell,  2012;  104 (10),  603 - 617
• Jiménez L, Aurrekoetxea M, Ibarretxe G, Garcia P, de-Vega S, Unda FJ  Reduced expression of tight junction proteins zo-1 and claudin-1 in ameloblasts and odontoblasts of epiprofin/sp6 deficient mice Bull Group Int Rech Sci Stomatol Odontol,  2011;  49,  102 - 103
• Badiola I, Olaso E, Crende O, Friedman SL, Vidal-Vanaclocha F  Discoidin Domain Receptor 2 deficiency. Predisposes hepatic tissue to colon carcinoma metastasis GUT,  2011;  Epub ahead of print
• Aurrekoetxea M, Ibarretxe G, García-Gallastegui P, Unda F  Alteration of tooth development in two-phase organotypic cultures by transient glycogen synthase kinase-3 (gsk-3) inhibition Bull Group Int Rech Sci Stomatol Odontol,  2011;  49,  100 - 101
• Badiola I  Discoidin Domain Receptors Role in Human Disease Notulae Scientia Biologicae,  2011;  3 (4),  7 - 12
• Talamillo A, Delgado I, Nakamura T, de‐Vega S, Yoshitomi Y, Unda F, Birchmeier W, Yamada Y, Ros MA  Role of Epiprofin, a zinc-finger transcription factor, in limb development Developmental Biology,  2010;  337 (2),  363 - 374
• Jimenez-Rojo L, Ibarretxe G, Aurrekoetxea M, de Vega S, Nakamura T, Yamada Y, Unda F  Epiprofin/Sp6: a new player in the regulation of tooth development Histology and Histopathology,  2010;  25 (12),  1621 - 1630
• Badiola I  MicroRNA Implication in Cancer Notulae Scientia Biologicae,  2010;  2 (1),  7 - 13
• Nakamura T, de Vega S, Fukumoto S, Jimenez L, Unda F, Yamada Y  Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number Journal of Biological Chemistry,  2008;  283 (8),  4825 - 4833
• Ibarretxe G, Perrais D, Jaskolski F, Vimeney A, Mulle C  Fast regulation of axonal growth cone motility by electrical activity Journal of Neuroscience,  2007;  27(29),  7684 - 7695
• Ibarretxe G, Alberdi E, Sánchez-Gómez MV, Campos MR, Matute C  Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols GLIA,  2006;  53,  201 - 211
• Bernborn N, Licht TR, Brogren CH, Jelle B, Johansen AH, Badiola I, Vogensen FK, Norrung B  Effects of Lactococcus lactis on Composition of Intestinal Microbiota: Role of Nisin Applied and Environmental Microbiology,  2006;  72 (1),  239 - 244
• Hu B, Unda F, Bopp‐Kuchler S, Jimenez L, Wang XJ, Haïkel Y, Wang SL, Lesot H  Bone marrow cells can give rise to ameloblast-like cells Journal of Dental Research,  2006;  85(5),  416 - 421
• Polo Y, Luzuriaga J, Gonzalez de Langarica S, Pardo-Rodríguez B, Martínez-Tong DE, Tapeinos C, Manero-Roig I, Marin E, Muñoz-Ugartemendia J, Ciofani G, Ibarretxe G, Unda F, Sarasua JR, Pineda JR*, Larrañaga*  Self-assembled three-dimensional hydrogels based on graphene derivatives and cerium oxide nanoparticles: scaffolds for co-culture of oligodendrocytes and neurons derived from neural stem cells Nanoscale IF: 8.3 (Q1),  15,  4488 - 4505