Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6–12 Years
- Autoría:
- Campos-Sánchez, I., Navarrete-Muñoz, E. M., Martens, D. S., Riaño-Galán, I., Lertxundi, A., Llop, S., Guxens, M., Rodríguez-Dehli, C., Lertxundi, N., Soler-Blasco, R., Vrijheid, M., Nawrot, T.S., Wright, J., Yang, T.C., Mceachan, R., Gützkow, K.B., Chatzi, V.L., Vafeiadi, M., Kampouri, M., Grazuleviciene, R., Andrusaityte, S., Lepeule, J., Valera-Gran, D.
- Año:
- 2025
- Revista:
- Journal of Attention Disorders
- Cuartil:
- Q2
- DOI:
- 10.1177/10870547251314923
- Descripción:
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Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years.
Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners’ Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.
Results: Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = .022).
Conclusion: While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.