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Título - Biología molecular

Doctoral Programme in Molecular Biology and Biomedicine

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Presentación - Biología molecular

The Doctoral Programme in Molecular Biology and Biomedicine has been ongoing at the UPV/EHU for over a decade, under different names. It aims to turn young graduates from different degree courses into professional scientists, specialising in the programme's principal disciplines.

The main objective of this doctorate is to train researchers through their immersion in top class research labs, which are recommended due to their productivity in defended doctoral theses and in quality publications derived from said theses.

Within the generic title of the programme, five main lines of research can be defined: membrane and protein biophysics, molecular biology of diseases, molecular genetics of cancer and autoimmunity, pathophysiology of lipids and lipidomic techniques, and cell signalling, proteomics and biotechnology.

The programme is mainly based at the Faculty of Science and Technology and the Faculty of Medicine and Nursing at the UPV/EHU, as well as at the Institute of Biophysics, the Biocruces Health Research Institute, and the Biogune/Biomagune Centres for Cooperative Research.

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Part-time studies

Duration: 5 - 8 cursos

Places available: 3

Approximate fees: 219 €/academic year

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Full-time studies

Duration: 3 - 5 cursos

Places available: 37

Approximate fees: 301 €/academic year


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Research teams and research topics

Research teams and research topics
Research teamsResearch topics
Team I. Biophysics
  • Advanced techniques for fluorescent spectroscopic micro- and nanoscopy
  • Biophysics of Systems and Computational Biology
  • Carotenoids and lipoproteins
  • Identification and characterization of proteins and lipids associated with regulators of cell excitability.
  • Insights into the structure, function and nucleocytoplasmic traffic of nuclear proteins
  • Inter-domain relationships in integral membrane proteins
  • Mechanism of action of peptide toxins which act on the membrane
  • Mechanisms of virus-induced membrane fusion
  • Membrane protein folding and stability. Structural motif engineering and design
  • Mitochondrial membranes, apoptosis and cancer
  • Nanomechanics of the cell membrane systems
  • Protein folding and the role of molecular chaperones
  • Role of cellular membranes in bacterial pathogenesis
  • Sphingolipids, "rafts" and membrane domains.
  • Structural Glycobiology
  • Structural studies of biomolecules by means of IR spectroscopy
  • X-ray crystallography and crystallization of proteins and viruses
Team II. CIC-bioGUNE
  • Cancer and aging
  • Infectious diseases
  • Metabolism and disease
  • Protein homeostasis.
Team III. Molecular Genetics
  • Characterization of the intracellular signalling pathways dependent on the amyloid 1-42 ß peptide
  • Conservation of local animal populations: population genetics
  • Cooperativity between the signalling regulated by the monomeric GTPases and the metabolism of glucose
  • Development of discriminating tools: agro-food traceability
  • Evaluation of the potential genotoxic capacity of anti-hypertensive drugs
  • Feeding behaviour, phenotype and associated genetic profile in humans
  • Function and regulation of human deubiquitinases
  • Genes modifying the age of the onset of Huntington's disease
  • Genetic and epigenetic characterization of cancer and mental illnesses
  • Genomic analysis of endogenous retroviruses
  • Identification of genes of economic importance: animal production and susceptibility/resistance to disease
  • Immunogenetics of autoimmune diseases: celiac disease and type 1 diabetes
  • Molecular biology of cancer and auto-immunity
  • Nucleocytoplasmic transport of proteins
  • Search for markers of resistance to infectious diseases and cancer in mammals
  • Study of the FMR1 gene
  • Study of the adaptation of microbial communities to the anthropogenic impact
Team IV. Molecular Physiopathology
  • Biology of hepatic lipid bodies
  • Free radicals and oxidative stress in human pathophysiology
  • Functional characterization of gene promoters
  • Functional genomics of SND1.
  • Hepatic regeneration
  • Molecular mechanisms involved in the origin and evolution of the disease of non-alcoholic fatty liver disease (NAFLD).
Team V. Cell Signalling, Proteomics and Biotechnology
  • Development and application of proteomic techniques
  • Enzymatic synthesis of biodiesel
  • Enzymatic synthesis of biosurfactants
  • Inflammation and carcinogenesis
  • Lipid metabolism and cell signalling
  • Obtaining of magnetic biocatalysts
  • Pharmacological, structural and functional study of vasopressin receptors
  • Plasticity and neuroprotection in the normal and pathological retina (glaucoma).
  • Purinergic signalling in macrophages and CHO cells
  • Ras superfamily proteins involved in the cellular signalling processes which regulate ion movement through the cell membrane
  • Synthesis and degradation of bioplastics