Ana María Zubiaga

Presentation

Phone: 94 601 2603
Email: ana.zubiaga@ehu.es
Office Location: Schoolof Science and Technology, Building F1, Ground floor, office 3
Research Group: MOLECULAR BIOLOGY OF CANCER

Teaching Profile

I teach the course Human Genetics in Basque language, a compulsory subject in the Degree in Biochemistry and Molecular Biology. Regarding post-graduate teaching, I teach the course Workshop in Molecular Biology, and I am one of the lecturers in the course Fundamentals of Genomics, Proteomics and Bioinformatics. These courses are part of the Masters degree in Molecular Biology and Biomedicine.

In addition, I supervise undergraduate student projectsin the Degree inBiochemistry and Molecular Biology, and master student projects in the Master in Molecular Biology and Biomedicine. 

I am general coordinator of the Interuniversity Masters degree in Molecular Biology and Biomedicine.

Research Profile

I earned my PhD degree in 1986 at the University of the Basque Country (UPV/ EHU) with a project on the Histophysiology of pulmonate gastropod molluscs. I carried out post-doctoral research (1986-1994) at the Universities of Tufts and Harvard (USA) in the field of genetic regulation of cell proliferation, specifically in the mechanisms that regulate the immune response and the role of cellular oncogenes.

Since my arrival to the UPV/EHU in 1995, my research focuses on the Biology of Cancer, particularly on the study of the molecular mechanisms regulated by the Retinoblastoma/E2F pathway, and the control of the cell cycle. Experimental designs in my research involve the use of cellular and animal genetic models.

I am responsible for the Gene Expression Unit, Research Facilities department, UPV/EHU.

I am a member of the Ethics Committee for Animal Research (CEBA) of the UPV/EHU, and en elected member of the Post-Graduate Committee of the UPV/EHU. I have collaborated as deputy with Agencia Nacional de Evaluación y Prospectiva (ANEP) (2005-2009), in the area of Molecular Cell Biology, and Genetics.

Research Projects (as Principal Investigator)

Project Title: Relevancia fisiológica de los factores E2F más allá de la regulación del ciclo celular 
Funding Organization: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD. MIMECO
Number of participating investigators: 4
Start date: 01/01/2016  End date: 31/12/2018

Project Title: Caracterización funcional y mecanismos de acción de los factores de transcripción típicos y atípicos de la familia E2F
Funding Organization: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD. Ref.: SAF2012-33551
Number of participating investigators: 6
Start date: 01/01/2013  End date: 31/12/2015

Project Title: Grupo de Investigación del Sistema Universitario Vasco. Mecanismos moleculares implicados en la alteración de la homeostasis celular: perspectivas para la terapia del cáncer
Funding Organization: GOBIERNO VASCO, Departamento Educación. Ref.: IT634-13
Participating Institutions: Universidad del País Vasco (UPV/EHU)
Number of participating investigators: 16
Start date: 01/01/2013  End date: 31/12/2018

Project Title: Caracterización funcional de fosforilaciones en los genes nme2 y de lrf2bpl asociadas a la activación celular
Funding Organization: GOBIERNO VASCO, Departamento Industria, Comercio y Turismo. Ref.: S-PE12UN144
Number of participating investigators: 3
Start date: 01/01/2012  End date: 31/12/2013

Project Title: Investigación estratégica y desarrollo tecnológico aplicado a metabolismo-enfermedad y cáncer-envejecimiento
Funding Organization: GOBIERNO VASCO, Departamento Industria, Comercio y Turismo. Ref.: IE12-331
Number of participating investigators: 12
Start date: 01/01/2012  End date: 31/12/2014 

Project Title: Cluster for molecular biomedicine education and research (CLUMBER)
Funding Organization: UPV/EHU
Participating Institutions: UPV/EHU. Ref.: UFI11/20
Number of participating investigators: 26
Start date: 01/01/2011  End date: 31/12/2014

Selected publications (last 5 years)

  • Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM. (2018) An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res. 2018 Mar 24. doi: 10.1093/nar/gky218
  • Iglesias-Ara A, Osinalde N, Zubiaga AM. (2018) Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay. Methods Mol Biol. 2018;1726:153-166. 
  • Iglesias-Ara A, Zubiaga AM. The stress of coping with E2F loss. Mol Cell Oncol. 2015 May 26;3(1):e1038423. 
  • Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM. (2016) E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 2016 Mar 9. 
  • Iglesias-Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga AM. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Cell Death Differ. 2015 Oct;22(10):1577-89. 
  • Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez JA, Fullaondo A, Zubiaga AM (2013) E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.Nucleic Acids Res. 2013 Dec;41(22):10185-98.  
  • Ochoa E, Iriondo M, Bielsa A, Ruiz-Irastorza G, Estonba A, Zubiaga AM. (2013) Thrombotic antiphospholipid syndrome shows strong haplotypic association with SH2B3-ATXN2 locus. PLoS One. 2013 Jul 3;8(7):e67897. 
  • Osinalde N, Olea M, Mitxelena J, Aloria K, Rodriguez JA, Fullaondo A, Arizmendi JM, Zubiaga AM (2013) The nuclear protein ALY binds to and modulates the activity of transcription factor E2F2. Mol Cell Proteomics. 2013 May;12(5):1087-98. 
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