Selected publications of the last 5 years.

  • García-Santisteban I, Llopis A, Krenning L, Vallejo-Rodriguez J, van den Broek B, Zubiaga* AM, Medema* RH. (* corresponding authors). Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells. BMC Biol. 2021 Feb 19;19(1):35. doi: 10.1186/s12915-021-00965-x.

    Rodriguez JA. The "STK38-XPO1 axis": its general relevance and mechanistic underpinnings remain to be further characterized.  Cell Mol Life Sci. 2021 Feb 9. doi: 10.1007/s00018-021-03778-x. Online ahead of print.

    Sendino M, Omaetxebarria MJ, Prieto G, Rodríguez JA. Using a Simple Cellular Assay to Map NES Motifs in Cancer-Related Proteins, Gain Insight into CRM1-Mediated NES Export, and Search for NES-Harboring Micropeptides. Int. J. Mol. Sci. 2020, 21, 6341; doi:10.3390/ijms21176341.

    Pascual-Itoiz MA, Peña-Cearra A, Martín-Ruiz I, Lavín JL, Simó C, Rodríguez H, Atondo E, Flores JM, Carreras-González A, Tomás-Cortázar J, Barriales D, Palacios A, García-Cañas V, Pellón A, Fullaondo A, Aransay AM, Prados-Rosales R, Martín R, Anguita J, Abecia L. The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis. Sci Rep. 2020 Jan 17;10(1):572. doi: 10.1038/s41598-019-57348-0.

    Peñalver-González B, Vallejo-Rodríguez J, Mentxaka G, Fullaondo A, Iglesias-Ara A, Field SJ, Zubiaga AM. Golgi Oncoprotein GOLPH3 Gene Expression Is Regulated by Functional E2F and CREB/ATF Promoter Elements. Genes (Basel). 2019 Mar 25;10(3). pii: E247. doi: 10.3390/genes10030247. 

    Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M. Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions. J Cell Biol. 2019 Sep 2;218(9):2865-2875. doi: 10.1083/jcb.201902085.

    Taylor J, Sendino M, Gorelick A, Pastore A, Chang M, Penson A, Gavrila E, Stewart C, Melnik E, Herrejon Chavez F, Bitner L, Yoshimi A, Chun-Wei Lee S, Inoue D, Liu B, Zhang X, Mato A, Kharas M, Dogan A, Chen Y, Wang D, Soni R, Hendrickson R, Prieto G, Rodriguez JA, Taylor B, Abdel-Wahab O. Altered nuclear export signal recognition as a driver of oncogenesis. Cancer Disc. 2019; 9:1452-1467

    Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J. 2019 Aug 15;38(16):e101379. doi: 10.15252/embj.2018101379.

    Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M. Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability. Mol Cell. 2019 Feb 21;73(4):670-683.e12. doi: 10.1016/j.molcel.2018.11.036.

    Mitxelena* J, Apraiz* A, Vallejo-Rodríguez* J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM. (* equal contribution). An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res. 2018 May 18;46(9):4546-4559. doi:10.1093/nar/gky218.

    Tomasi ML, Ramani K, Ryoo M, Cossu C, Floris A, Murray BJ, Iglesias-Ara A, Spissu Y, Mavila N. SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease. FASEB J. 2018 :fj201701124R. doi: 10.1096/fj.201701124R. 

    Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M. Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance. Nat Commun. 2018 Jul 11;9(1):2678. doi: 10.1038/s41467-018-05031-9.

    Iglesias-Ara A, Osinalde N, Zubiaga AM. Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay. Methods Mol Biol. 2018;1726:153-166. doi: 10.1007/978-1-4939-7565-5_14.

    Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez JA, McCutcheon JN, Rahhal R, Alberobello AT, Wang Y, Zhang Y-W, Guha U, Giaccone G. Therapeutic effects of XPO1 inhibition in thymic epithelial tumors. Cancer Res. 2017; 77(20): 5614–5627

    Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Oncotarget. 2017; 8(45):78851-78869. doi: 10.18632/oncotarget.20234. 

    Osinalde N, Mitxelena J, Sánchez-Quiles V, Akimov V, Aloria K, Arizmendi JM, Zubiaga AM, Blagoev B, Kratchmarova I. Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes. Mol Cell Proteomics. 2016 Jun;15(6):2076-92. doi: 10.1074/mcp.M115.057158.

    Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM. E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 2016 Jul 8;44(12):5557-5570. doi: 10.1093/nar/gkw146.

    Prieto G, Fullaondo A, Rodríguez JA. Proteome-wide search for functional motifs altered in tumors: Prediction of nuclear export signals inactivated by cancer-related mutations. Sci Rep. 2016 May 12;6:25869. doi: 10.1038/srep25869.

    García-Santisteban I,  Arregi I, Alonso-Mariño M, Urbaneja MA, Garcia-Vallejo JJ, Bañuelos S, Rodriguez JA. A cellular reporter to evaluate CRM1 nuclear export activity. Functional analysis of the cancer-related mutant E571K. Cell. Mol. Life Sci. 2016; 73(24):4685-4699.