Cátedra Miguel Sánchez-Mazas

For uncomplicated urinary tract infections (UTIs), fosfomycin 3gm sachet is often prescribed as a single-dose regimen. Fosfomycin tromethamine, the salt form of fosfomycin, is commonly used due to its effectiveness against a wide range of bacteria commonly responsible for UTIs, including Escherichia coli.

The single-dose regimen of fosfomycin offers several advantages. Firstly, it provides convenience to patients, as they only need to take one dose, usually in the form of a powder or granules dissolved in water. This simplicity can improve medication adherence and reduce the burden on patients compared to multi-day antibiotic regimens. Additionally, the high concentration of fosfomycin achieved in the urine shortly after ingestion ensures effective treatment of the infection at the site of action.

The efficacy of fosfomycin as a single-dose treatment for UTIs has been well-documented in clinical studies. Research has shown comparable cure rates between fosfomycin and other commonly prescribed antibiotics for uncomplicated UTIs, such as nitrofurantoin and trimethoprim-sulfamethoxazole.

However, it's essential to note that the single-dose regimen may not be appropriate for all UTIs. In cases of complicated UTIs, recurrent infections, or infections caused by multidrug-resistant bacteria, a longer course of antibiotics or alternative treatment options may be necessary. Additionally, healthcare providers may consider factors such as the patient's medical history, previous antibiotic use, and local antimicrobial resistance patterns when determining the most appropriate treatment regimen.

While fosfomycin is generally well-tolerated, like all antibiotics, it can cause side effects such as gastrointestinal upset, diarrhea, and allergic reactions in some individuals. Patients should follow their healthcare provider's instructions carefully and report any adverse effects experienced during treatment.

In conclusion, a single dose of fosfomycin is often sufficient for the treatment of uncomplicated UTIs, offering convenience and effectiveness. However, healthcare providers should individualize treatment regimens based on the specific circumstances of each patient and the characteristics of the infection to ensure optimal outcomes