Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of α-aminophosphonic acid derivatives
- Autoría:
- Francisco Palacios, Tomasz K. Olszewski, Javier Vicario
- Año:
- 2010
- Revista:
- Organic & Biomolecular Chemistry
- Volumen:
- 8
- Página de inicio - Página de fin:
- 4255 - 4258
- Descripción:
-
Efficient synthesis of α-aminophosphonic acid derivatives is achieved, the key step being a diastereoselective hydrophosphonylation of N-diphenylphosphinyl imines using a readily available chiral cyclic (R,R)-TADDOL-phosphite derived from inexpensive natural tartaric acid.