Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor
- Autoría:
- Kinga Radwan-Olszewska, Francisco Palacios, Pawel Kafarski
- Año:
- 2011
- Revista:
- The Journal of Organic Chemistry
- Volumen:
- 76
- Página de inicio - Página de fin:
- 1170 - 1173
- Descripción:
-
A series of α-mono- and α,α-difluoro-β-ketophosphonates were synthesized in moderate to good yields with excellent selectivities via electrophilic fluorination by Selectfluor. Subsequently, synthetic potential of the obtained α-monofluoro-β-ketophosphonates was demonstrated by their application in synthesis of α-monofluoro-β-aminophosphonates, useful building blocks in the preparation of phosphapeptides.