The course aims to enable students to apply their basic knowledge on reactivity of organic functional groups to the preparation of simple compounds, select the appropriate experimental techniques, and apply criteria of separation and purity of organic compounds. For this reason, it is highly recommended to do the course entitled “Organic Chemistry I” simultaneously.

SKILLS OF THE ESSENTIAL MODULE to be worked in this course



1. (MO2CM03)Ability to plan and carry out in the laboratory simple synthetic procedures and characterization of chemical compounds safely and using proper techniques, and to evaluate the data derived from experimental observations in the various fields of chemistry

2. (MO2CM010)Ability to search for and select information in the field of chemistry and other scientific fields using the literature sources and information technologies

3. (MO2CM09)Ability to explain phenomena and processes related to chemistry, orally and in writing.

1. Reduction reactions. Chemoselectivity

2. Elimination Reactions: dehydration of alcohols

3. Aromatic Electrophilic Substitution: Nitration of a benzene derivative

4. Addition-Elimination reactions on the carbonyl group: Fischer Estherification

5. Bimolecular nucleophilc Substitution reactions (SN2): Preparation of iodides from alkyl bromides

6. Electrophilic addition to alkenes: Electrophilic bromination

7. Aldol condensation

8. Protection of functional groups: protection of the carbonyl group as an acetal.

9. Addition of organometallic reagents to the carbonyl group: Grignard reagents.

Students are given a lab-book with the detailed experimental procedures that will be carried out in the laboratory. It is always necessary to prepare in advance the experiment by reading and understanding the experimental procedure, and fully understanding the experimental techniques that are going to be used. It is also important to be aware of the potential danger related to the handling of certain reagents, and laboratory safety regulations. These topics are discussed during the Class sessions (GA), prior to the Lab sessions. During the lab sessions (GL), the experimental work is carried out and results are obtained, requiring strict implementation of laboratory safety regulations. The students are expected to be able to write a lab notebook correctly, and are requested submit a report on the experiment the week after each of the experiments. Special emphasis is given to the correct description and wording of the experimental procedures in the reports. Exercises related to the lab experiments and results obtained in the lab will be discussed during Seminars (S).

• Continuous Assessment System
• Final Assessment System
• Tools and qualification percentages:
  • Written test to be taken (%): 20
  • Realization of Practical Work (exercises, cases or problems) (%): 35
  • Individual works (%): 25
  • Practical laboratory exam (%): 20

In the ordinary call, the final grade will be the result of the following parts:



1. Laboratory Work. Students' work during the lab sessions will be graded according to the following criteria: skill with experimental techniques, results, tidiness, lab notebook, answers to questions... Weighting in the final grade: 35%. It is compulsory to fulfill the complete practical program. Minimum: 5



2. Individual work. Reports. The student is requested to submit lab reports after completion of each experiment; these will be revised and corrected by the instructor and given back to the student. The following aspects will be taken into account for grading purposes: presentation, results and discussion of the experiment, conciseness, correct use of technical language in the redaction of experimental procedures... All reports and questionnaries should be presented. Overdue reports will not be marked. Weighting in the final grade: 25%. Pass Mark: 5



3. Practical laboratory exam: this consists of a practical experiment carried out individually in the lab, related to those done during the course. The student must present the lab notebook, written during the lab sessions and signed by the instructor. This notebook can be used as reference material during the exam. Percentage in the final grade: 20% Minimum: 5



4. Theory and practical exam: Written exam on the concepts covered during the experimental sessions or on situations covered in seminars and class sessions. Weighting in the final grade: 20% Minimum: 5



Students who decline to be evaluated (NP), should indicate this in writing before the beginning of the second semester.



According to the Grading Regulations in Undergraduate Studies, students who do not wish to participate in the Continuous assesment system, should indicate this in writing to their instructor before the end of week 18. In any case, it is compulsory to fulfill the complete practical program.

In the extraordinary call, the final qualification will be the result of the following parts:





1. Individual work. Corrected reports on the experiments done during the course. Presentation, results and discussion of the experiment, redaction of experimental procedures, and answers to questions will be qualified. All reports should be presented. Weighting in the final grade: 25%. Minimum: 5



2. Practical laboratory exam: consists on a practical experiment carried out in the lab, equal or related to the ones done during the course. The student will work individually. The student must present the lab notebook, written during the lab sessions and signed by the instructor. This notebook could be used by the student as reference material during the exam. Weighting in the final grade: 55% Minimum: 5



3. Theory and practical exam: Written exam on the concepts covered during the experimental sessions or on situations covered in seminars and class sessions. Weighting in the final grade: 20% Minimum: 5

Safety goggles, lab coat, spatula, lab notebook, gloves, lab safety regulations

Basic bibliography

1. M. J. Rodríguez, F. Gómez, CURSO EXPERIMENTAL EN QUÍMICA ORGÁNICA, Síntesis, 2008.

2. M. A. Martínez, A. Csákÿ, TÉCNICAS EXPERIMENTALES EN SÍNTESIS ORGÁNICA, Síntesis, 2005.

3. J. W. Zubrick, THE ORGANIC CHEM LAB SURVIVAL MANUAL. A STUDENT'S GUIDE TO TECHNIQUES, 8th Edition, John Wiley and Sons, 2010.

4. R. H. Hill, D. C. Finster LABORATORY SAFETY FOR CHEMISTRY STUDENTS, John Wiley and Sons, 2010

5. P. B. Cranwell, L. M. Harwood, C. J. Moody, EXPERIMENTAL ORGANIC CHEMISTRY, 3rd edition, John Wiley & Sons: Chichester, 2017.

6. J. Isac-García, J. A. Dobado, F. G. Calvo-Flores, H. Martínez García, EXPERIMENTAL ORGANIC CHEMISTRY. LABORATORY MANUAL, Academic Press: Londres, 2016.

In-depth bibliography

1.D. L. Pavia; G. M. Lampman; G. S. Kriz; R. G. Engell, INTRODUCTION TO ORGANIC LABORATORY TECHNIQUES. A MICROSCALE APPROACH, 3ª Ed., Saunders College Publishing, Fort Worth, 1999.
2.D. W. Mayo; R. M. Pike,; P. K. Trumper, MICROSCALE ORGANIC LABORATORY, 3ª Ed., John Wiley and Sons, New York, 1994.
3. Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, C. A. M. Alfonso, N. R. Candeias, D. Pererira Simao, A. F. Trincade, J. A. S. Coleho, B. Tan, R. Franzén, Editores; Royal Society of Chemistry, Londres, 2017.

Journals

Organic Syntheses: http://www.orgsyn.org/
The Journal of Organic Chemistry: http://pubs.acs.org/journal/joceah
Organic Letters: http://pubs.acs.org/journal/orlef7
European Journal of Organic Chemistry: http://www3.interscience.wiley.com/journal/27380/home
Organic and Biomolecular Chemistry: http://www.rsc.org/Publishing/Journals/Ob/Index.asp
Journal of Chemical Education:http://jchemed.chem.wisc.edu/

Web addresses

Quiored: Recursos educativos en Química Orgánica:http://www.ugr.es/~quiored/
Organic Chemistry Portal: http://www.organic-chemistry.org/
Organic Resources Wordwide: http://www.organicworldwide.net/
Bases de datos de compuestos orgánicos: http://pubchem.ncbi.nlm.nih.gov/ , http://www.chemspider.com/
Handbook of Chemistry & Physics Online!: http://www.hbcpnetbase.com/