Phone: 94 601 5799
Email: ainhoa.iglesias@ehu.es
Office Location: School of Science and Technology, Building F1, ground floor, office 6
Research Group: MOLECULAR BIOLOGY OF CANCER

ORCID: 0000-0002-2056-8213

Research ID: H-3021-2015

I began my University teaching in 2010.  Currently, I teach two subjects in the Degree in Biology: Genetics, a compulsory subject, in Basque, and Genetic Engineering and Molecular Genetic Analysis, an elective subject, in Spanish. I supervise graduate student projects in the Degree in Biology and the Degree in Biochemistry and Molecular Biology as well as master student projects within the Master in Molecular Biology and Biomedicine. In addition, during the last years, I have assumed responsibilities related to academic management, as a member of various commissions of the Faculty of Science and Technology of the UPV/EHU.

I received my doctorate in 2006 from the University of the Basque Country (UPV/EHU) with a work on the role of the Retinoblastoma/E2F pathway in the control of pancreatic and hematopoietic function. I completed my postdoctoral research activity (2006-2008) at the University of Southern California (USA), in the field of Methionine Metabolism and liver cancer, in the group led by Dr. Shelly C. Lu, with whom I continue maintaining a close collaboration. Since my reincorporation at the UPV / EHU, my research activity has been carried out in the research group led by Dr. Ana M. Zubiaga, making use of cell and animal genetic models to elucidate the role of key proteins in tumor suppression.

Gonzalez-Romero F, Mestre D, Aurrekoetxea I, O'Rourke CJ, Andersen JB, Woodhoo A, Tamayo-Caro M, Varela Rey M, Palomo-Irigoyen M, Gómez-Santos B, Sáenz de Urturi D, Núñez-García M, García-Rodríguez JL, Fernández-Ares L, Buqué X, Iglesias-Ara A, Bernales I, Gutierrez De Juan V, Delgado TC, Goikoetxea-Usandizaga N, Lee R, Bhanot S, Delgado I, Perugorria MJ, Errazti G, Mosteiro L, Gaztambide S, Martinez de la Piscina I, Iruzubieta P, Crespo J, Banales JM, Martínez-Chantar ML, Castaño L, Zubiaga AM, Aspichueta P. E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment. Cancer Res. 2021 Mar 26:canres.2052.2020. doi: 10.1158/0008-5472.CAN-20-2052. Online ahead of print.

Floris A, Mazarei M, Yang X, Robinson AE, Zhou J, Barberis A, D'hallewin G, Azara E, Spissu Y, Iglesias-Ara A, Orrù S, Tomasi ML. SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract. Biomolecules. 2020 Mar 31;10(4):529. doi: 10.3390/biom10040529.

Peñalver-González B, Vallejo-Rodríguez J, Mentxaka G, Fullaondo A, Iglesias-Ara A, Field SJ, Zubiaga AM. Golgi Oncoprotein GOLPH3 Gene Expression Is Regulated by Functional E2F and CREB/ATF Promoter Elements. Genes (Basel). 2019 Mar 25;10(3). pii: E247. doi: 10.3390/genes10030247.

Tomasi ML, Ramani K, Ryoo M, Cossu C, Floris A, Murray BJ, Iglesias-Ara A, Spissu Y, Mavila N. SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease. FASEB J. 2018 :fj201701124R. doi: 10.1096/fj.201701124R. 

Iglesias-Ara A, Osinalde N, Zubiaga AM. Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay. Methods Mol Biol. 2018;1726:153-166. doi: 10.1007/978-1-4939-7565-5_14.

Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Oncotarget. 2017; 8(45):78851-78869. doi: 10.18632/oncotarget.20234.

Iglesias-Ara A, Zubiaga AM. The stress of coping with E2F loss. Mol Cell Oncol. 3, pp. : e1038423. 2016.

Iglesias-Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga AM. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Cell Death Differ. 2015; 22:1577 -1589.