Cardiovascular disease: study of molecular mechanisms and design of new theranostic tools (TeraCardiovascular)


Department (s)
Biochemistry and Molecular Biology

Knowledge area
Biochemistry and molecular biology, medicine, nanobiotechnology, biophysics
PI: César Martín Plágaro Co-PI: 


César Martin Plágaro; Asier Benito Vicente; Iratxe Rojo Bartolome; Unai Galicia Garcia; Shifa Jebari Benslaiman; Asier Larrea Sebal


Dyslipidemia, cardiovascular, recombinant HDL nanoparticle, cholesterol, atherosclerosis


Cardiovascular diseases are the main cause of mortality worldwide and one of the main factors that contribute to the development of disease is atherosclerosis. Our research group has established new methodologies to characterize the pathogenicity of LDLR, APOB and PCSK9 variants, the main genes causing familial hypercholesterolemia.

Our interest is focused on the development of new diagnostic and therapeutic tools that contribute to the development of personalized medicine. For this we have developed an algorithm based on machine-learning that predicts the pathogenicity of mutations in LDLR. We are also developing an atherosclerotic tool based on the development of recombinant HDL, functionalized with different microRNAs to promote the reverse transport of cholesterol and reduce the inflammatory state of atherosclerotic lesions.

Research lines

  1. Functional characterization of LDLR, APOB and PCSK9 variants
  2. Study of the development of type 2 diabetes in response to statin treatment
  3. Development of rHDL for theranostic of cardiovascular disease
  4. Development of nanocarrier systems for antiatherogenic drugs


  • Jasco 8100 (Japan) spectropolarimeter. Peltier thermostatization
  • Bruker Hyperion 1000 Microspectroscope
  • AKTA, chromatograph columns
  • RT-PCR/qRT-PCR thermocyclers.
  • Flow cytometer FACS LSR II instrument (BD Biosciences, San Jose, CA) and data were analyzed using the FlowJo software (Tree Star, Ashland, OR).
  • NanoWizard II AFM (JPKInstruments, Germany). Atomic Force Microscopy
  • Multispectral Confocal Microscopy
  • Epifluorescence-TIRF microscope
  • Olympus IX 81 confocal microscope, with sequential excitation and image capture by Axiocam NRc5 digital

Website link