Many congratulations to all the team from the Microfluidics Cluster UPV/EHU participating in this new publication in Analytica Chimica Acta (IF: 5.256 (2018), Q1)

The publication entitle: "Naked Eye Y Amelogenin Gene Fragment Detection Using DNAzymes on a Paper-based Device" by Enrique Azuaje-Hualde, Susana Arroyo-Jimenez, Gaizka Garai-Ibabe, Marian M. de Pancorbo, Fernando Benito-Lopez and Lourdes Basabe-Desmonts presents a methodology for in situ single strand DNA detection by using a colorimetric assay based on the formation of a DNAzyme within a paper substrate. A DNAzyme that could only be formed in the presence of a specific sequence of the Y human amelogenin gene was designed. The performance of the DNAzyme was followed colorimetrically first in solution and then in paper substrates. The reaction was found to be specific to the Y fragment selected as analyte. The DNAzyme reaction on paper enabled the unequivocal colorimetric identification of the Y single strand DNA fragment both qualitatively, with the naked eye (143 ng), and quantitatively by image analysis (45.7 ng). As a proof of concept, a microfluidic paper-based device, pre-loaded with all DNAzyme reagents, was characterized and implemented for the simultaneous detection of X and Y single strand DNA fragments.

Congratulations. Great job!!!!