Enantiopure chiral molecules are essential for the development of new pharmaceuticals, advanced materials, and emerging technologies, yet their selective synthesis remains one of the major challenges in modern chemistry. Our group designs sustainable asymmetric catalytic processes by combining metal catalysis, organocatalysis, and biocatalysis, selecting in each case the most efficient strategy. These experimental studies are complemented by computational chemistry, which allows us to understand reactivity, elucidate reaction mechanisms, and uncover the origin of selectivity. Recently, our research has focused on a relatively unexplored yet highly promising type of chirality: planar chirality. This form of asymmetry, present in rigid systems with conformational constraints, opens new regions of chemical space and enables access to molecules with unique properties, with promising applications in the design of pharmaceuticals, advanced materials, and optical devices.