MOLECULAR STRATEGIES FOR CONTROLLING THE SPREAD OF ANTIBIOTIC RESISTANCE (CONJURA)
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| Knowledge area Life and Health Sciences (Molecular Biology; Biochemistry; Biotechnology; Biotechnology; Infectious Diseases) |
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| PI: Miren Itziar Alkorta Calvo | Co-PI: | |
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Members Lide Arana, Ianire Mate, Emma González Peral, Kepa Arbe, Ana Rey, Arnau Calvet, Sara Arrieta, Nagore Santos |
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Keywords Antibiotic resistance, multi-resistant bacteria, conjugative plasmids, coupling proteins, horizontal gene transfer, Solid Lipid Nanoparticles, drug delivery |
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Description Misuse and abuse of antibiotics has exerted the selective pressure responsible for the emergence of multi- and pan-resistant bacteria. If we do not take action, there is a risk of running out of effective antibiotics. Bacterial conjugation is the main process by which bacteria acquire resistance to antibiotics. Therefore, our group aims to find specific inhibitors of bacterial conjugation to minimise the spread of antibiotic resistance among bacteria. Solid Lipid Nanoparticles (SLNs) can improve the therapeutic and bioavailability properties of many therapeutic molecules. Our group is working to improve the properties of available antibiotics by encapsulating them in SLNs. |
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