Microsystem Integration

The lab-on-a-chip field of research and technology development aims to provide to the society and the researchers with analytical devices able to integrate and to automate a sequence of steps: from sample preparation, analysis to results reporting. Such development requires the integration of surface engineering approaches, flow control systems, sensors and microfluidic architectures, all adapted to well characterized analytical protocols. Microsystems integration constitutes a big challenge, and requires the coordinated work of a multidisciplinary team. We are developing specific workflow designs to be able to integrate the different components and protocols developed in our group to produce functional microsystems. We work on the development of the following integrated microsystems:

1- Devices for nucleic acid purification and analysis.


2- Water analysis devices.


3- Disposable, wearable devices for sweat analysis.


4- Microfluidic platform for cell culture and monitoring.

Image
(A) Centrifugal water analysis system. (B) Handheld sensor device. (C) pH microfluidic sensor device.

Most Relevant Group Publications

Type 1 Diabetes Mellitus Reversal Via Implantation of Magnetically Purified Microencapsulated Pseudoislets, A. Espona-Noguera, J. Etxeberria-Elezgarai, L. Saenz del Burgo, A. Cañibano-Hernández, H. Gurruchaga, F. J. Blanco, G. Orive, R. M. Hernández, F. Benito-Lopez; J. Ciriza, L. Basabe-Desmonts*, J. L. Pedraz*, Int. J. Pharm., 2019, 560, 65-77.

Ionogel-based Nitrite and Nitrate Sensor for Water Control at the Point-of-Need, J. Saez, G. Arana, L. A. Fernandez-Cuadrado, F. Benito-Lopez*, Procedia Eng. 2016, 168, 518-521.

Smartphone Application for Determination of pH and Nitrites Concentration Using a Paper-Based Microfluidic Device, N. Lopez-Ruiz, V. F. Curto, M. M. Erenas, F. Benito-Lopez, D. Diamond , A. J. Palma, L. F. Capitan-Vallvey, Anal. Chem. 2014, 86, 9554−9562.