nireEHU 
Subject
Molecular Basis of Cell Proliferation, Differentiation and Death
General details of the subject
- Mode
- Face-to-face degree course
- Language
- English
Teaching staff
| Name | Institution | Category | Doctor | Teaching profile | Area | |
|---|---|---|---|---|---|---|
| ARRUABARRENA ARISTORENA, AMAIA | University of the Basque Country | Investigador Ramón Y Cajal | Doctor | Not bilingual | ** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l" | amaia.arruabarrena@ehu.eus |
| CARRACEDO PEREZ, ARKAITZ | University of the Basque Country | Investigador Distinguido | Doctor | Bilingual | ** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l" | arkaitz.carracedo@ehu.eus |
| MAYOR MARTINEZ, UGO | University of the Basque Country | Visitante Ikerbaske | Doctor | Not bilingual | Biochemistry and Molecular Biology | ugo.mayor@ehu.eus |
| MICHELENA SANCHEZ, JONE | University of the Basque Country | Visitante Ikerbaske | Doctor | Not bilingual | Genetics | jone.michelena@ehu.eus |
| PEREIRO DIEZ, XANDRA | University of the Basque Country | Doctor | Not bilingual | ** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l" | xandra.pereiro@ehu.eus | |
| RODRIGUEZ PEREZ, JOSE ANTONIO | University of the Basque Country | Profesorado Agregado | Doctor | Bilingual | Genetics | josean.rodriguez@ehu.eus |
| RUIZ LARREA, MARIA BEGOÑA | University of the Basque Country | Profesorado Titular De Universidad | Doctor | Not bilingual | Physiology | mbego.ruizlarrea@ehu.eus |
| RUIZ SANZ, JOSE IGNACIO | University of the Basque Country | Profesorado Agregado | Doctor | Not bilingual | Physiology | joseignacio.ruizs@ehu.eus |
| TORRANO MOYA, VERONICA | University of the Basque Country | Investigador Ramón Y Cajal | Doctor | Not bilingual | ** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l" | veronica.torrano@ehu.eus |
| VECINO CORDERO, ELENA | University of the Basque Country | Profesorado Catedratico De Universidad | Doctor | Not bilingual | Histology | elena.vecino@ehu.eus |
| BARRIO OLANO, MARIA ROSA | Centro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE) | Otros | Doctor | rbarrio@cicbiogune.es | ||
| KYPTA , ROBERT | Centro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE) | Otros | Doctor | rkypta@cicbiogune.es | ||
| SUTHERLAND , JAMES DAVID | Centro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE) | Otros | Doctor | |||
| VIVANCO RUIZ, MARIA DEL MAR | Centro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE) | Otros | Doctor | mdmvivanco@cicbiogune.es |
Study types
| Type | Face-to-face hours | Non face-to-face hours | Total hours |
|---|---|---|---|
| Lecture-based | 25 | 38 | 63 |
| Seminar | 25 | 37 | 62 |
Training activities
| Name | Hours | Percentage of classroom teaching |
|---|---|---|
| Analysing and discussing papers | 50.0 | 40 % |
| Drawing up reports and presentations | 40.0 | 25 % |
| Expositive classes | 35.0 | 57 % |
Assessment systems
| Name | Minimum weighting | Maximum weighting |
|---|---|---|
| Attendance and participation | 0.0 % | 6.5 % |
| Questions to discuss | 0.0 % | 3.5 % |
Learning outcomes of the subject
Appreciate how on-going advances in biomedicine stem from an increasingly detailed knowledge of basic cellular processes.Integrate different fundamental aspects of molecular and cellular biology as elements to open novel avenues of research in the biomedical field.
Critically assess scientific results presented in primary research reports on molecular and cellular biology.
Ordinary call: orientations and renunciation
The evaluation will be based on the following aspects:1. Attendance and participation in class 65% of the final grade. 80% class attendance is required. 2. Scientific report 45% of the final grade.
Extraordinary call: orientations and renunciation
Written assessment of the entire course program.Temary
Topic 1: SIGNALING PATHWAYS INVOLVED IN GROWTH AND DIFFERENTIATION. CELL RECEPTORS. CELL ADHESION. RAS, TGF, WNT, PI3K, MAPK PATHWAYS.Topic 2: PHYSIOPATHOLOGY OF NUCLEOCYTOPLASMIC TRANSPORT.
Topic 3: SIGNALING PATHWAYS INVOLVED IN CELL SURVIVAL. OXIDATIVE METABOLISM.
Topic 4: GENE REGULATION AND HUMAN DISEASE.
Topic 5: POST-TRANSCRIPTIONAL MECHANISMS REGULATING CELL PROLIFERATION. PROTEIN UBIQUITINATION.
Topic 6: MOLECULAR BASES OC CELL CYCLE. CELL DIVISION AND CANCER.
Topic 7: EDITING THE GENOME USING CRISPR.
Topic 8: MOLECULAR MECHANISMS OF CELL DEATH. APOPTOSIS AND CANCER.
Topic 9: MOLECULAR MECHANISMS OF STEM CELL RENEWAL AND DIFFERENTIATION.
Topic 10 MOLECULAR MECHANISMS IN TISSUE REGENERATION.
Bibliography
Compulsory materials
For each individual subject included in the program the student will be provided by the instructors with additional teaching aids (i.e Power Point presentations and other specialized references as reviews or research articles).Basic bibliography
EWIN, B. GENES VIII. PEARSON PRENTICE HALL, NJ INTERNATIONAL EDITION. 2004.STEIN, GS AND PARDEE, AB. CELL CYCLE AND GROWTH CONTROL. 2ND EDITION. JOHN WILEY AND SONS, INC, NJ. 2004.
LATCHMAN, D. GENE REGULATION. A EUKARYOTIC PERSPECTIVE. 4TH EDITION. CHELTENHAM: NELSON THORNES LTD. 2002.
El-DEIRY, WAKIF. TUMOR SUPPRESSOR GENES: REGULATION, FUNCTION AND MEDICINAL APPLICATIONS. HUMANA PRESS. 2002.
ALBERTS, B. ET AL. MOLECULAR BIOLOGY OF THE CELL. 6TH EDITION. GARLAND PUBLISHING, NY, 2014.
Selected papers from scientific journals: NATURE, SCIENCE, CELL, MOLECULAR CELL, EMBO J, NATURE GENETICS. These papers will be discussed in the seminars.