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Molecular Basis of Cell Proliferation, Differentiation and Death

General details of the subject

Mode
Face-to-face degree course
Language
English

Teaching staff

NameInstitutionCategoryDoctorTeaching profileAreaE-mail
ARRUABARRENA ARISTORENA, AMAIAUniversity of the Basque CountryInvestigador Ramón Y CajalDoctorNot bilingual** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l"amaia.arruabarrena@ehu.eus
CARRACEDO PEREZ, ARKAITZUniversity of the Basque CountryInvestigador DistinguidoDoctorBilingual** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l"arkaitz.carracedo@ehu.eus
MAYOR MARTINEZ, UGOUniversity of the Basque CountryVisitante IkerbaskeDoctorNot bilingualBiochemistry and Molecular Biologyugo.mayor@ehu.eus
MICHELENA SANCHEZ, JONEUniversity of the Basque CountryVisitante IkerbaskeDoctorNot bilingualGeneticsjone.michelena@ehu.eus
PEREIRO DIEZ, XANDRAUniversity of the Basque CountryDoctorNot bilingual** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l"xandra.pereiro@ehu.eus
RODRIGUEZ PEREZ, JOSE ANTONIOUniversity of the Basque CountryProfesorado AgregadoDoctorBilingualGeneticsjosean.rodriguez@ehu.eus
RUIZ LARREA, MARIA BEGOÑAUniversity of the Basque CountryProfesorado Titular De UniversidadDoctorNot bilingualPhysiologymbego.ruizlarrea@ehu.eus
RUIZ SANZ, JOSE IGNACIOUniversity of the Basque CountryProfesorado AgregadoDoctorNot bilingualPhysiologyjoseignacio.ruizs@ehu.eus
TORRANO MOYA, VERONICAUniversity of the Basque CountryInvestigador Ramón Y CajalDoctorNot bilingual** n o c o n s t a e l a r e a * ó " á r e a p r o v i s i o n a l"veronica.torrano@ehu.eus
VECINO CORDERO, ELENAUniversity of the Basque CountryProfesorado Catedratico De UniversidadDoctorNot bilingualHistologyelena.vecino@ehu.eus
BARRIO OLANO, MARIA ROSACentro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE)OtrosDoctorrbarrio@cicbiogune.es
KYPTA , ROBERTCentro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE)OtrosDoctorrkypta@cicbiogune.es
SUTHERLAND , JAMES DAVIDCentro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE)OtrosDoctor
VIVANCO RUIZ, MARIA DEL MARCentro de Investigacion Cooperativa en Biociencias (CIC-bioGUNE)OtrosDoctormdmvivanco@cicbiogune.es

Study types

TypeFace-to-face hoursNon face-to-face hoursTotal hours
Lecture-based253863
Seminar253762

Training activities

NameHoursPercentage of classroom teaching
Analysing and discussing papers50.040 %
Drawing up reports and presentations40.025 %
Expositive classes35.057 %

Assessment systems

NameMinimum weightingMaximum weighting
Attendance and participation0.0 % 6.5 %
Questions to discuss0.0 % 3.5 %

Learning outcomes of the subject

Appreciate how on-going advances in biomedicine stem from an increasingly detailed knowledge of basic cellular processes.

Integrate different fundamental aspects of molecular and cellular biology as elements to open novel avenues of research in the biomedical field.

Critically assess scientific results presented in primary research reports on molecular and cellular biology.

Ordinary call: orientations and renunciation

The final grade will be based on the following aspects:

1. Attendance and participation in class: 65% of the final grade.

2. Written assignment: 35% of the final grade.



Attendance is compulsory. Excused absences may be made up for with the activity indicated by the person in charge of the session.



The intervention of the student in the classes will be valued, the questions and comments made in each session will be valued. A high participation and attendance to 100% of the sessions allows passing the course.



An unexcused attendance of less than 80% of the sessions will result in the failure of the course.

In the case of absence with a justified cause (more than 30%), an exam/test of the subject adjusted to the specific situation will be carried out.



Extraordinary call: orientations and renunciation

The extraordinary call will involve the realization of an exam/test of the subject that will consist of the development of a topic of the subject to choose between two chosen at random.



Temary

Topic 1: SIGNALING PATHWAYS INVOLVED IN GROWTH AND DIFFERENTIATION. CELL RECEPTORS. CELL ADHESION. RAS, TGF, WNT, PI3K, MAPK PATHWAYS.



Topic 2: PHYSIOPATHOLOGY OF NUCLEOCYTOPLASMIC TRANSPORT.



Topic 3: SIGNALING PATHWAYS INVOLVED IN CELL SURVIVAL. OXIDATIVE METABOLISM.



Topic 4: GENE REGULATION AND HUMAN DISEASE.



Topic 5: POST-TRANSCRIPTIONAL MECHANISMS REGULATING CELL PROLIFERATION. PROTEIN UBIQUITINATION.



Topic 6: MOLECULAR BASES OC CELL CYCLE. CELL DIVISION AND CANCER.



Topic 7: EDITING THE GENOME USING CRISPR.



Topic 8: MOLECULAR MECHANISMS OF CELL DEATH. APOPTOSIS AND CANCER.



Topic 9: MOLECULAR MECHANISMS OF STEM CELL RENEWAL AND DIFFERENTIATION.



Topic 10 MOLECULAR MECHANISMS IN TISSUE REGENERATION.

Bibliography

Compulsory materials

For each individual subject included in the program the student will be provided by the instructors with additional teaching aids (i.e Power Point presentations and other specialized references as reviews or research articles).

Basic bibliography

EWIN, B. GENES VIII. PEARSON PRENTICE HALL, NJ INTERNATIONAL EDITION. 2004.



STEIN, GS AND PARDEE, AB. CELL CYCLE AND GROWTH CONTROL. 2ND EDITION. JOHN WILEY AND SONS, INC, NJ. 2004.



LATCHMAN, D. GENE REGULATION. A EUKARYOTIC PERSPECTIVE. 4TH EDITION. CHELTENHAM: NELSON THORNES LTD. 2002.



El-DEIRY, WAKIF. TUMOR SUPPRESSOR GENES: REGULATION, FUNCTION AND MEDICINAL APPLICATIONS. HUMANA PRESS. 2002.



ALBERTS, B. ET AL. MOLECULAR BIOLOGY OF THE CELL. 6TH EDITION. GARLAND PUBLISHING, NY, 2014.



Selected papers from scientific journals: NATURE, SCIENCE, CELL, MOLECULAR CELL, EMBO J, NATURE GENETICS. These papers will be discussed in the seminars.

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