Learning outcomes of the subject

The student will acquire a critical scientific approach, capacity for experimental design and scientific communication in the field of macromolecule structure.

The student will acquire practical skills in the appropriate techniques to address problems of a basic or applied nature in the determination and analysis of the structure of macromolecules.

The student will acquire the knowledge, skills and abilities necessary to carry out an innovative research project in the field of macromolecule structure.

The student will know how to apply advanced knowledge and techniques in Biochemistry, Structural Biology and Molecular Biology to the study and understanding of the structure and function of macromolecules.

The student will acquire self-learning skills that will allow continuous updating in methodological and conceptual advances related to the structure of macromolecules.

Ordinary call: orientations and renunciation

Attendance is compulsory. Excused absences may be made up with the activity indicated by the person in charge of the session.



The intervention of the student in the classes will be valued, the questions and comments made in each session will be valued. A high participation and attendance to 100% of the sessions allows to pass the course.



An unexcused attendance of less than 80% of the sessions will result in the failure of the course.

In the case of absence with a justified cause (more than 30%), an exam/test of the subject adjusted to the specific situation will be carried out.



The evaluation tests of the course will be adjusted to the characteristics of the group and will be made explicit at the beginning of the course.

Extraordinary call: orientations and renunciation

The extraordinary call will involve the realization of an exam/test of the subject that will consist of the development of a topic of the subject to choose between two chosen at random.

Temary

Tema 1 INTRODUCCIÓN A LA ESTRUCTURA DE PROTEÍNAS

Tema 2 ESTRUCTURA SECUNDARIA DE PROTEÍNAS

Tema 3 TÉCNICAS ESPECTROSCÓPICAS PARA ESTIMAR LA ESTRUCTURA SECUNDARIA DE PROTEÍNAS Y DETERMINAR MECANISMOS DE REACCIÓN

Tema 4 ESTRUCTURA TERCIARIA Y CUATERNARIA DE PROTEÍNAS

Tema 5 PROTEÍNAS DE MEMBRANA

Tema 6 DETERMINACIÓN DE LA ESTRUCTURA TERCIARIA DE PROTEÍNAS I: CRISTALOGRAFÍA Y DIFRACCIÓN DE RAYOS X

Tema 7 DETERMINACIÓN DE LA ESTRUCTURA TERCIARIA DE PROTEÍNAS II: MICROSCOPÍA ELECTRÓNICA

Tema 8 ESTABILIDAD TERMODINÁMICA DE PROTEÍNAS

Tema 9 PLEGAMIENTO DE PROTEÍNAS EN LA CÉLULA

Tema 10 PLEGAMIENTO DEFECTUOSO Y ENFERMEDADES

Tema 11 PREDICCION ESTRUCTURA DE PROTEINAS

Tema 12 MOTORES MOLECULARES

Tema 13 NANOBIOTECNOLOGÍA

Tema 14 ESTRUCTURA Y TOPOLOGÍAS DEL DNA

Tema 15 ESTRUCTURA SECUNDARIA Y TERCIARIA DE RNAS

Tema 16 RECONOCIMIENTO MACROMOLECULA-LIGANDO

Tema 17 INTERACCIONES MACROMOLECULARES

Tema 18 EVOLUCION MOLECULAR DE PROTEINAS

Tema 19 INGENIERIA DE PROTEINAS

Bibliography

Compulsory materials

For each individual subject included in the program the student will be provided by the instructors with additional teaching aids (i.e Power Point presentations and other specialized references as reviews or research articles)in the digital platform Moodle.

Basic bibliography

1) Gómez-Moreno, C y Sancho, J (coordinadores) "ESTRUCTURA DE PROTEÍNAS". Ed. Ariel 2003

2) Creigthon, T. "PROTEINS. STRUCTURE AND MOLECULAR PROPERTIES" 2ª ed. Freeman. 1993

3) Branden, Tooze. "INTRODUCTION TO PROTEIN STRUCTURE" 2ª ed. Garland 1999

4) LESK, A. "AN INTRODUCTION TO PROTEIN ARCHITECTURE: THE STRUCTURAL BIOLOGY OF PROTEINS." OXFORD UNIVERSITY PRESS, 2001

5) Kyte "STRUCTURE IN PROTEIN CHEMISTRY", Garland 1995

6) Darby, Creigthon "PROTEIN STRUCTURE" IRL Press. Oxford University Press 1993

7) Rhodes, G "CRYSTALLOGRAPHY MADE CRYSTAL CLEAR". 2ª ed. Academic Press 2000

8) Sinden, "DNA STRUCTURE AND FUNCTION". Academic Press, 1994.

9) Blomfield, Crothers, Tinoco, "NUCLEIC ACIDS: STRUCTURE, PROPERTIES AND FUNCTION". University Science Books, 2000