Irakasgaiaren azalpena eta testuingurua

Homeostasis depends crucially on a proper balance between cell proliferation, differentiation and death. In fact, defects of these key processes underlie many human diseases, such as cancer. Thus, dissecting the exceedingly complex molecular mechanisms that control how cells proliferate, differentiate and die is a major goal of current biomedical research.

In this context, the subject “Molecular bases of cell proliferation, differentiation and death” aims to extend and deepen the understanding of these mechanisms that students have acquired during their undergraduate training. Students are provided with updated information on several aspects of molecular and cellular biology, and are prompted to critically analyze the reports of research findings.

Importantly, the faculty of the subject is a group of selected researchers that are actively working on different aspects of the molecular bases of cell proliferation, differentiation and death. Therefore, students are exposed to first-hand experiences of how current research on this areas is being carried out.

Irakasgai-zerrenda

Topic 1

SIGNALING PATHWAYS INVOLVED IN GROWTH AND DIFFERENTIATION. I. CELL RECEPTORS. CELL ADHESION.

Topic 2

SIGNALING PATHWAYS INVOLVED IN GROWTH AND DIFFERENTIATION. II. RAS, TGF, WNT, PI3K, MAPK

Topic 3

SIGNALING PATHWAYS INVOLVED IN CELL SURVIVAL. OXIDATIVE METABOLISM.

Topic 4

GENE REGULATION AND HUMAN DISEASE

Topic 5

POST-TRANSCRIPTIONAL MECHANISMS REGULATING CELL PROLIFERATION. PROTEIN UBIQUITINATION.

Topic 6

MOLECULAR BASES OC CELL CYCLE. CELL DIVISION AND CANCER.

Topic 7

SPATIAL ORGANIZATION OF THE GENOME. GENOMIC INSTABILITY.

Topic 8

MOLECULAR MECHANISMS OF CELL DEATH. APOPTOSIS AND CANCER.

Topic 9

MOLECULAR MECHANISMS OF STEM CELL RENEWAL AND DIFFERENTIATION. TELOMERS AND SENESCENCE.

Topic 10

MOLECULAR MECHANISMS IN CANCER AND INFLAMATION. ANIMAL MODELS.

Bibliografia

Oinarrizko bibliografia

EWIN, B. GENES VIII. PEARSON PRENTICE HALL, NJ INTERNATIONAL EDITION. 2004.

STEIN, GS AND PARDEE, AB. CELL CYCLE AND GROWTH CONTROL. 2ND EDITION. JOHN WILEY AND SONS, INC, NJ. 2004.

LATCHMAN, D. GENE REGULATION. A EUKARYOTIC PERSPECTIVE. 4TH EDITION. CHELTENHAM: NELSON THORNES LTD. 2002.

El-DEIRY, WAKIF. TUMOR SUPPRESSOR GENES: REGULATION, FUNCTION AND MEDICINAL APPLICATIONS. HUMANA PRESS. 2002.

ALBERTS, B. ET AL. MOLECULAR BIOLOGY OF THE CELL. 6TH EDITION. GARLAND PUBLISHING, NY, 2014.

Selected papers from scientific journals: NATURE, SCIENCE, CELL, MOLECULAR CELL, EMBO J, NATURE GENETICS. These papers will be discussed in the seminars.